Arithmetic Abilities in Children With 22q11.2DS

Not Applicable

Terminated

• Conditions: 22q11.2 Deletion Syndrome
• Interventions: Behavioral: Magnitude comparison tasks and neuropsychological testing

• Registration Number: NCT04373226
• Lead Sponsor: Hôpital le Vinatier

Brief Summary

The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.

Detailed Description

Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.

Study Timeline

• Study First Submitted: 2020-04-30
• Study First Submitted QC: 2020-04-30
• Study First Posted: 2020-05-04
• Study Start: 2020-09-16
• Primary Completion: 2023-04-14
• Study Completion: 2023-04-14
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-04
• Last Update Posted: 2025-03-07

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Diagnosis of 22q11.2 deletion syndrome or no developmental disease
• Aged from 4 to 11 years old
• French language

Exclusion Criteria

• Diagnosis of intellectual deficiency according to DSM 5 criteria
• Drug prescribed for somatic condition that could influence cerebral functioning

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
22q11.2DS	Magnitude comparison tasks and neuropsychological testing	Children aged from 4 to 11 years old with 22q11.2 deletion syndrome
NON22q11.2DS	Magnitude comparison tasks and neuropsychological testing	Children aged from 4 to 11 years old without developmental disease

Primary Outcome Measures

Name	Time	Method
Percentage of impaired scaled score	single day	percentage of impaired scaled score at ZAREKI-R

Secondary Outcome Measures

Name	Time	Method
Percentage of correct responses	single day	percentage of correct responses in magnitude comparisons tasks
Mean reaction time	single day	mean reaction time in magnitude comparison tasks

Trial Locations

Locations (1)

Hopital Vinatier; 🇫🇷 Lyon, Rhone Alpes, France