Effects of Acetate on Insulin Sensitivity, CNS regulation of food intake and appetite in Humans
- Conditions
- metabolic syndrome
- Registration Number
- NL-OMON21096
- Lead Sponsor
- Amsterdam University Medical Centersm location AMC
- Brief Summary
are planned end 2022
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion criteria healthy lean subject group:
- Healthy Caucasian male or female
- Age 40-65
- Women must be post-menopausal
- BMI range of 19-25 kg/m2
- Subjects should be able and willing to give informed consent.
Inclusion criteria obese metabolic syndrome subject group:
- Caucasian male or female with metabolic syndrome
- Age 40-65
- Women must be post-menopausal
- BMI range of 25-40 kg/m2
- At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose = 5.6 mmol/L and/or HOMA-IR = 2.5, triglycerides = 1.6 mmol/L, waist-circumference > 102 cm, HDL cholesterol = 1.04 mmol/L, blood pressure = 130/85.
- Subjects should be able and willing to give informed consent.
Exclusion criteria for all participants
- Systemic medication use, except for paracetamol
- Oral or intravenous antibiotics in the past 3 months before inclusion
- Smoking
- Substance abuse
- Contra-indication for MRI, such as claustrophobia or pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br>The main objective of this study is to look at the effect of iv acetate infusion on postprandial glucose metabolism and whether this effect differs between healthy lean subjects and obese subjects with metabolic syndrome.
- Secondary Outcome Measures
Name Time Method <br>The secondary objectives of this study are to study the effects of acetate infusion on postprandial lipid and SCFA metabolism, plasma glucagon-like peptide-1 (GLP-1) and ghrelin levels, subjective ratings of appetite and CNS regulation of appetite