Oxygenation during noninvasive ventilation: active valve- versus leak-circuit

Not Applicable

• Conditions: J96.1; Chronic respiratory failure

• Registration Number: DRKS00000449
• Lead Sponsor: niversitätsklinikum Freiburg, Abteilung Innere Medizin V - Pneumologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2010-08-05
• Study Start: 2010-10-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Patients with stable hypercapnic chronic respiratory failure (CRF) on NPPV with supplemental oxygen of at least 2 L/min will be enrolled. Patients are referred to the Department of Pneumology of the University Hospital Freiburg for a routine control visit of their NPPV.

Exclusion Criteria

Patients who presented with an acute exacerbation (respiratory frequency 30 breaths/min, pH <7.35 or clinical signs of infection), those planned for weaning from invasive ventilation or those who had been intubated or tracheostomised during the previous 3 months will be excluded.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference of FiO2 at FiO2-sensor 2 (at the interface) between active valve circuit and leak circuit

Secondary Outcome Measures

Name	Time	Method
Mean transcutaneous PCO2, oxygen saturation (SaO2), Subjective ventilation quality