on-invasive mechanical ventilation with average volume assured pressure support (AVAPS) in hypercapnic encephalopathy
- Conditions
- Infectious exacerbations of COPD and hypercapnic encephalopathyRespiratory
- Registration Number
- ISRCTN05135218
- Lead Sponsor
- San Francisco de Quito University (Universidad San Francisco de Quito) (Ecuador)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 22
1. Age > 40 years
2. COPD was diagnosed on the basis of the recommendations of the American Thoracic Society
3. Hypercapnic encephalopathy with GCS < 10 were designated to receive BiPAP S/T with AVAPS
4. The control group was then selected from patients in the emergency unit with infectious exacerbations of COPD and encephalopathy (GCS < 10). Patients were treated immediately and referred to us by doctors who were unaware of the study. Each patient was treated with NIV and was selected according to: Acute Physiology and Chronic Health Evaluation II (APACHE II) score within 4 points, age within 10 points, pH within 0.04, GCS within 2 points, and BMI within 2 points
5. Informed consent
1. A face deformity
2. Obstruction of the upper respiratory tract owing to recent surgery or trauma
3. Alterations in the central nervous system not related to a hypercapnic encephalopathy
4. Cardiogenic pulmonary edema, pneumothorax, pulmonary thromboembolism, hemoptysis, or septic shock
5. Urgent intubation owing to cardiac and/or respiratory arrest, and hemodynamic instability with a systolic arterial blood pressure (BP) of less than 80mmH
6. Other neurological illness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evel of consciousness (Glasgow Coma Scale score)
- Secondary Outcome Measures
Name Time Method 1. Duration of mechanical ventilation<br>2. Hospital stay, and <br>3. Progression (exhaled tidal volume, inspiratory pressure, and arterial blood gases)