ISRCTN05135218
Completed
N/A
on-invasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease and hypercapnic encephalopathy: prospective interventional match-controlled study
San Francisco de Quito University (Universidad San Francisco de Quito) (Ecuador)0 sites22 target enrollmentSeptember 18, 2012
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Infectious exacerbations of COPD and hypercapnic encephalopathy
- Sponsor
- San Francisco de Quito University (Universidad San Francisco de Quito) (Ecuador)
- Enrollment
- 22
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age \> 40 years
- •2\. COPD was diagnosed on the basis of the recommendations of the American Thoracic Society
- •3\. Hypercapnic encephalopathy with GCS \< 10 were designated to receive BiPAP S/T with AVAPS
- •4\. The control group was then selected from patients in the emergency unit with infectious exacerbations of COPD and encephalopathy (GCS \< 10\). Patients were treated immediately and referred to us by doctors who were unaware of the study. Each patient was treated with NIV and was selected according to: Acute Physiology and Chronic Health Evaluation II (APACHE II) score within 4 points, age within 10 points, pH within 0\.04, GCS within 2 points, and BMI within 2 points
- •5\. Informed consent
Exclusion Criteria
- •1\. A face deformity
- •2\. Obstruction of the upper respiratory tract owing to recent surgery or trauma
- •3\. Alterations in the central nervous system not related to a hypercapnic encephalopathy
- •4\. Cardiogenic pulmonary edema, pneumothorax, pulmonary thromboembolism, hemoptysis, or septic shock
- •5\. Urgent intubation owing to cardiac and/or respiratory arrest, and hemodynamic instability with a systolic arterial blood pressure (BP) of less than 80mmH
- •6\. Other neurological illness
Outcomes
Primary Outcomes
Not specified
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