ACTRN12613000940774
Recruiting
N/A
oninvasive ventilation-neurally adjusted ventilatory assist (NIV-NAVA) compared to noninvasive ventilation-pressure support (NIV-PS) in post-extubated subjects on synchrony and work of breathing
Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital0 sites17 target enrollmentAugust 26, 2013
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Department of Intensive Care, Pamela Youde Nethersole Eastern Hospital
- Enrollment
- 17
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Are currently or previously on mechanical ventilation for acute respiratory failure
- •2\.Are considered fit for extubation (defined as hemodynamic stability without the need for vasopressor support and a heart rate less than 110 beats per minute (bpm), respiratory rate less than 30 per minutes, and a Glasgow coma scale of E4VtM6\), or has been extubated already
- •3\.Are indicated for NIV with \>\=1 of the risk factors for reintubation, including: chronic heart failure, COPD initially intubated because of an episode of acute hypercapnic respiratory failure, age \>65, more than one consecutive failure of weaning trial before extubation, PaCO2 \>45 mmHg (6 kPa) after extubation, weak cough
- •4\.Expected to require NIV for \>\=2 days
- •5\.Able to give consent to the study by him/herself.
Exclusion Criteria
- •patients less than 18 years of age, pregnancy, with contraindications for insertion of nasogastric tube, or with contraindications for NIV (esophageal varices or obstruction, bleeding of the upper gastrointestinal tract, recent gastroesophageal surgery, hemodynamic instability or severe arrhythmia, facial surgery or trauma or deformity, severe upper airway obstruction, inability to cooperate or protect the airways, inability to cough or clear respiratory secretions, absence of a gag reflex and severe gastric distention), or contraindications to NAVA mode (known or suspected phrenic nerve dysfunction, and impaired respiratory drive).
Outcomes
Primary Outcomes
Not specified
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