A randomised trial of expedited transfer to a cardiac arrest centre for non-ST elevation out of hospital cardiac arrest

Not Applicable

Completed

• Conditions: Cardiac arrest; Circulatory System

• Registration Number: ISRCTN96585404
• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30092413 protocol 2017 Other publications in https://www.ncbi.nlm.nih.gov/pubmed/28174052 pilot study (added 17/02/2020) 2023 Results article in https://doi.org/10.1016/S0140-6736(23)01351-X (added 23/07/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-14
• Study Completion: 2024-04-30
• Last Update Posted: 5 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 900

Inclusion Criteria

Current participant inclusion criteria as of 14/02/2020:
1. Out-of-hospital cardiac arrest (OHCA)
2. Return of spontaneous circulation (ROSC)
3. Aged 18 or over (known or presumed)

Previous inclusion criteria as of 27/09/2016:
1. Witnessed out-of-hospital cardiac arrest
2. Return of spontaneous circulation and 12-lead electrocardiogram
3. Age 18 or over (known or presumed)
4. No obvious non-cardiac cause (trauma, drowning, suicide, drug overdose)

Previous inclusion criteria:
1. Witnessed out-of-hospital cardiac arrest
2. Absence of non-cardiac cause (trauma, drowning, intoxication)
3. Presenting rhythm: pulseless VT or VF

Exclusion Criteria

Current participant exclusion criteria as of 14/02/2020:
1. Criteria for ST-elevation myocardial infarction on 12-Lead electrocardiogram (ECG)
2. Do Not Attempt Resuscitation (DNAR) Order
3. Cardiac arrest suffered after care pathway set and patient en route
4. Suspected pregnancy
5. Presumed non-cardiac cause (for example; trauma, drowning, suicide, drug overdose)
6. Presumed significant trauma/injury

Previous exclusion criteria as of 27/09/2016:
1. Criteria for ST-elevation myocardial infarction on 12-lead electrocardiogram
2. Do Not Attempt Resuscitation Order
3. Suspected pregnancy

Previous exclusion criteria:
1. ST-elevation myocardial infarction (STEMI) on 12-lead ECG in presence of return of spontaneous circulation (ROSC)
2. Pulseless electrical activity (PEA) or Asystole (non-shockable) as the only documented rhythm
3. Do Not Attempt Resuscitation Order (DNAR)
4. Suspected pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All-cause mortality at 30 days