Effects of Polyphenols-rich Tropical Fruits on Mental Health Protection - A Clinical Trial among Middle-aged Women
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 31
研究概览
简要总结
Age-related decline in mental health and cognitive function usually starts to show its sign during middle-age and is greatly affected by dietary factors. Polyphenols have recently received attention in its role to improve various health issues related to aging, including decline in mental health and cognitive status. The study aimed to determine the effects of polyphenols-rich TP 3-in-1™ juice in improving mental health, cognitive status, selected biochemical parameters and metabolomics profiles. Middle-aged women with signs of poor mental health and cognitive status were randomised to receive either polyphenols-rich TP 3-in-1™ juice (n=16) or placebo (n=15). Supplementation was given for three days in a week (three times in the day of beverage consumption) for a period of ten weeks. There were significant interaction effects on RAVLT immediate recall and Comprehensive Trail Making Test (CTMT) Trail 4. Metabolomics analysis showed the presence of metabolites related to polyphenols intake and cognitive functions. Early detection of poor mental health and cognitive status is crucial to prevent further decline among the middle-aged adults. Supplementation of TP 3-in-1™ juice for 10 weeks has the potential to improve cognitive status.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 45 Years 至 59 Years（—）
- 性别
- Female
入选标准
- •Had poor score in at least three out of the seven categories of mental health (General Health Questionnaire-28) and cognitive status (as assessed using Rey Auditory Verbal Learning Test (RAVLT)
排除标准
- •1. Change of dietary habits for the past 3 months
- •2. Subjects with history of mental illness (Alzheimer's disease, schizophrenia, history of stroke)
- •3. Physical disability
- •4. Pregnant and lactating women
- •5. Women who are on hormone-replacement therapy
- •6. Subjects with chronic diseases (eg. diabetes, hypertension, hyperlipidemia, cancer etc)
- •7. Subjects who took any food supplements or/and regular polyphenols-rich fruits (more than 2 servings/day for the past 3 months prior to the study)