Evaluation of antioxidant effects of NAC and vitamin B6 in comparison with NAC and placebo, in chemical warfare victims Chronic pulmonary lesions
Phase 3
Recruiting
- Conditions
- war chemical gas pulmonary disease.Chronic respiratory conditions due to chemicals, gases, fumes and vaporsJ68.4
- Registration Number
- IRCT20080901001165N54
- Lead Sponsor
- Vice Chancellor for Research, Baqiyatallah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 56
Inclusion Criteria
Chronic lung lesions caused by war chemical gases have been proven;
According to the patient's spirometry results, the pulmonary injury is not severe;
The patient should have freely informed written consent to participate in the study.
Exclusion Criteria
Suffering from lung function-related diseases of lung origin, including asthma, bronchiectasis, etc.
Suffering from lung function-related diseases of non-lung origin, including ALS, kyphosis, etc.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Spirometry parameters changes. Timepoint: Before intervention, then 6 weeks later. Method of measurement: Spirometer.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: Before intervention, then 6 weeks later. Method of measurement: ACT Questionnaire.;Total antioxidant capacity. Timepoint: Before intervention, then 6 weeks later. Method of measurement: Total Antioxidant Capacity Assay Kit.;Malondialdehyde (MDA). Timepoint: before intervention, then 6 weeks later. Method of measurement: human Elisa kit.;Superoxide dismutase (SOD). Timepoint: before intervention, then 6 weeks later. Method of measurement: human Elisa kit.