Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis
- Sponsor
- University of Iowa
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Change in Isotonic Double Leg-press 1 Repetition Maximum Strength Scaled to Body Mass
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength and size, leg muscle power, and mobility in women at risk for developing symptomatic knee osteoarthritis. The primary outcome will be change in isotonic double leg-press 1 repetition maximum (1RM) strength. The investigators will test the following hypotheses. In comparison with low-intensity resistance training without use of PBFR, a four-week low-intensity resistance-training program with PBFR will:
Primary Hypothesis: Increase (a) double leg-press 1RM strength and (b) isokinetic knee extensor strength
Secondary Hypotheses:
- Increase quadriceps muscle volume assessed by MRI
- Increase lower limb muscle power on (a) double leg-press at 40% 1RM and (b) a timed stair climb
- Not adversely effect knee pain or quality of life assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire
Investigators
Neil A Segal
Associate Professor
University of Iowa
Eligibility Criteria
Inclusion Criteria
- •Age 45-65
- •BMI greater than or equal to 25 kg/m2, or a history of a knee joint injury or surgery, or knee symptoms (pain, aching, or stiffness) on most of the last 30 days, or knee osteoarthritis
Exclusion Criteria
- •Resistance training at any time in the last 3 months prior to study
- •Bilateral knee replacement
- •Lower limb amputation
- •Lower limb surgery in the last 6 months that affects walking ability or ability to exercise
- •Back, hip or knee problems that affect walking ability or ability to exercise
- •Unable to walk without a cane or walker
- •Inflammatory joint or muscle disease such as rheumatoid or psoriatic arthritis or polymyalgia rheumatica
- •Multiple sclerosis
- •Known neuropathy
- •Self-report of Diabetes
Outcomes
Primary Outcomes
Change in Isotonic Double Leg-press 1 Repetition Maximum Strength Scaled to Body Mass
Time Frame: 4 weeks
Secondary Outcomes
- Change in Quadriceps Muscle Volume by Magnetic Resonance Imaging(4 weeks)
- Change in Isokinetic Knee Extensor Strength(4 weeks)
- Change in Knee Injury and Osteoarthritis Outcome Score Pain Subscale(4 weeks)
- Change in Lower Limb Muscle Power by Double Leg-press at 40% 1 Repetition Maximum(4 weeks)