Covert-saccades, Dynamic Visual Acuity and Quality of Life

Not Applicable

Completed

• Conditions: Vestibular Diseases
• Interventions: Other: Head Impulse Tests; Other: Dynamic visual acuity Test (DVAT); Other: VEMPs & VEMPo; Other: Dizziness Handicap Inventory; Other: Oscillopsia severity questionnaire

• Registration Number: NCT02753179
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2016-04-25
• Study First Submitted QC: 2016-04-26
• Study First Posted: 2016-04-27
• Study Start: 2016-05
• Status Verified: 2017-01
• Primary Completion: 2017-01
• Study Completion: 2017-01
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria

  • Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
  • Pathologic Head-impulse test
  • VOR gain of <0.25 on rotatory chair tests

• Disorder present for over 6 month

• Comprehension of the experiments instructions

• Patient consent

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Exclusion Criteria

• Corrected Visual Acuity lower than 5/10
• Other conditions leading to oscillopsia or ataxia
• Oculomotor palsy, ocular instability in primary position
• Cervical rachis pathology with instability
• Cochlear Implants
• Non-stabilized medical disease
• Pregnant women
• Patients under tutelage

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Bilateral vestibular hypofunction	Dizziness Handicap Inventory	Patients suffering from chronic bilateral vestibular hypofunction.
Bilateral vestibular hypofunction	VEMPs & VEMPo	Patients suffering from chronic bilateral vestibular hypofunction.
Bilateral vestibular hypofunction	Oscillopsia severity questionnaire	Patients suffering from chronic bilateral vestibular hypofunction.
Bilateral vestibular hypofunction	Head Impulse Tests	Patients suffering from chronic bilateral vestibular hypofunction.
Bilateral vestibular hypofunction	Dynamic visual acuity Test (DVAT)	Patients suffering from chronic bilateral vestibular hypofunction.

Primary Outcome Measures

Name	Time	Method
Frequency of covert-saccades	Day 0	Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100.

Secondary Outcome Measures

Name	Time	Method
Oscillopsia severity questionnaire score	day 0	Oscillopsia severity questionnaire is a 9 items questionnaires that identify oscillopsia in different circumstances. A mean item score gives an oscillopsia severity score ranging from 1 to 5, yielding to a total score ranging from 0 to 45
Latency of covert-saccades	Day 0	Latency of covert saccades correspond to the time between the beginning of head impulse and the initiation of the first covert-saccade
Dynamic visual acuity	day 0	Dynamic visual acuity is a measure of threshold for binocular reading of letters that are presented on a screen during head impulse test
Quality of life assessed with the Dizziness Handicap Inventory	Day 0	Dizziness Handicap Inventory is a questionnaire that identify difficulties that patient may be experiencing because of dizziness, yielding to a score ranging from 0 to 100

Trial Locations

Locations (1)

Unité de Neuro-Ophtalmologie Hôpital Neurologique; 🇫🇷 Bron, France