Covert-saccades, Dynamic Visual Acuity and Quality of Life

Not Applicable

Completed

• Conditions: Vestibular Diseases

• Registration Number: NCT02753179
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-04-25
• Study First Submitted QC: 2016-04-26
• Study First Posted: 2016-04-27
• Study Start: 2016-05-01
• Primary Completion: 2017-01
• Study Completion: 2017-01-01
• Status Verified: 2025-08
• Last Update Submitted: 2025-08-27
• Last Update Posted: 2025-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria

  • Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
  • Pathologic Head-impulse test
  • VOR gain of <0.25 on rotatory chair tests

• Disorder present for over 6 month

• Comprehension of the experiments instructions

• Patient consent

Exclusion Criteria

• Corrected Visual Acuity lower than 5/10
• Other conditions leading to oscillopsia or ataxia
• Oculomotor palsy, ocular instability in primary position
• Cervical rachis pathology with instability
• Cochlear Implants
• Non-stabilized medical disease
• Pregnant women
• Patients under tutelage

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Frequency of covert-saccades	Day 0	Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100.

Secondary Outcome Measures

Name	Time	Method
Dynamic visual acuity	day 0	Dynamic visual acuity is a measure of threshold for binocular reading of letters that are presented on a screen during head impulse test
Quality of life assessed with the Dizziness Handicap Inventory	Day 0	Dizziness Handicap Inventory is a questionnaire that identify difficulties that patient may be experiencing because of dizziness, yielding to a score ranging from 0 to 100
Oscillopsia severity questionnaire score	day 0	Oscillopsia severity questionnaire is a 9 items questionnaires that identify oscillopsia in different circumstances. A mean item score gives an oscillopsia severity score ranging from 1 to 5, yielding to a total score ranging from 0 to 45
Latency of covert-saccades	Day 0	Latency of covert saccades correspond to the time between the beginning of head impulse and the initiation of the first covert-saccade

Trial Locations

Locations (1)

Unité de Neuro-Ophtalmologie Hôpital Neurologique; 🇫🇷 Bron, France