Effect of Nicorandil on contrast media-induced acute kidney injury
- Conditions
- Acute renal failure.Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
- Registration Number
- IRCT2016033118389N4
- Lead Sponsor
- Qom University of Medical Sciences and Health Services Vice chancellor
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 128
The inclusion criteria were the existence of at least one risk factor of contrast-induced nephropathy, including 1) Moderate systolic heart failure [30% < (EF) Ejection fraction < 45%] 2) Diabetes 3) Age> 75 years 4) Moderate renal insufficiency (1/5mg/ dL< Cr < 2mg/ dL 5) Hypotension (systolic blood pressure < 90 mm Hg 6) Anemia 7) History of hypertension Exclusion criteria: 1- Pregnancy and lactation 2- Allergy to radiographic contrast 3- Have cardiogenic shock and pulmonary edema during study 4- emergency catheterization 5- Serum creatinine levels> 2 mg/dL and preexisting dialysis 6- Exposure to contrast medium 48 h pre- and post-coronary angiography 7- Receive of diuretics, N-acetylcystein, sodium bicarbonate, Theophylline, Dopamine, Fenoldopam and NSAID’S during the study 8- Needs to continuous hydration therapy (e.g., sepsis) 9-severe heart failure (EF<=30%)
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum creatinine. Timepoint: Before and 48 h after contrast intake. Method of measurement: laboratory Kit (enzymatic method).
- Secondary Outcome Measures
Name Time Method