The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria

Not Applicable

Completed

• Conditions: Spinocerebellar Atrophy (SCA)
• Interventions: Other: Temporal electrical stimulation

• Registration Number: NCT01983670
• Lead Sponsor: Chang Gung University

Brief Summary

In individuals with spino-cerebellar atrophy (SCA), the delayed onset of antagonist muscle firing has been reported to be the cause of hypermetria. Hypermetria is a common deficit in individuals with spino-cerebellar atrophy SCA when they perform ballistic goal-directed movement. Based on the previous studies, ballistic goal-directed movements are controlled by a triphasic pattern of agonistic and antagonistic muscle activation. The origin of the EMG pattern is a central program, whereas the delayed onset of antagonistic muscle firing has been reported to be the cause of hypermetria. To develop a therapy method, the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements should be further investigated.

Traditional rehabilitations of individuals with cerebellum lesion were limited to improve the functional performance of movement. Since the deficits of the goal-directed movement are at pre-movement programming, only feedforward training will be possible to re-establish an appropriate program.

Previous showed that peripheral stimulation resulted in a facilitation of motor cortex. Our group also found that this facilitation in individuals with SCA was similar to the ones without SCA. Therefore, it is possible to adjust the control pattern of supraspinal excitability of agonist and antagonist busts of SCA patient with passively providing electrical stimulation contains normal control pattern of healthy human.

The present study sought to investigate the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07
• Primary Completion: 2012-06
• Study Completion: 2012-06
• Status Verified: 2013-11
• Study First Submitted: 2013-11-07
• Study First Submitted QC: 2013-11-07
• Last Update Submitted: 2013-11-07
• Study First Posted: 2013-11-14
• Last Update Posted: 2013-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Clinical diagnosis of spinocerebellar ataxia

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
health group 1	Temporal electrical stimulation	Health subjects received 30 mins delay antagonist activation temporal ES.
SCA group 1	Temporal electrical stimulation	SCA subjects received four weeks temporal ES assisted home training program.

Primary Outcome Measures

Name	Time	Method
Muscle evoked potential(MEP)	Baseline, 4 weeks.	Measure of changes in MEP of flexor carpi radialis.
Electromyography(EMG)	Baseline, 4 weeks	Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.
Movement error	Baseline, 4weeks	Measure of changes in movement error during fast 30 degrees wrist extensions.

Trial Locations

Locations (1)

Chang Gung University; 🇨🇳 Taoyuan, Taiwan