A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma
- Conditions
- BRAF Mutant Metastatic MelanomaCancer - Malignant melanoma
- Registration Number
- ACTRN12611000311954
- Lead Sponsor
- GlaxoSmithKline
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 200
1) Adults at least 18 years of age
2) Has advanced (unresectable Stage III) or metastatic (Stage IV) melanoma that is BRAF mutation positive (V600E)
3) Is treatment naive for advanced (unresectable) or metastatic melanoma, with the exception of Interleukin 2 (IL-2) which is allowed.
4) Has measurable disease according to RECIST 1.1 criteria.
5) Women of child-bearing potential must have a negative pregnancy test within 14 days prior to the first dose of study treatment.
5) Women with reproductive potential must be willing to practice acceptable methods of birth control during the study and for up to 4 weeks after the last dose of study medication.
6) Men with reproductive potential must be willing to practice acceptable methods of birth control during the study and for up to 16 weeks after the last dose of study medication.
7) Must have adequate organ function.
8) Must have Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1.
1) Currently receiving cancer therapy (chemotherapy, radiation therapy, immunotherapy, biologic therapy or surgery).
2) Evidence of active central nervous system (CNS) disease.
3) Previous treatment for metastatic melanoma, including treatment with BRAF or MEK inhibitor.
4) A history of other malignancy. Subjects who have been disease-free for 5 years or subjects with a history of complete resected non-melanoma skin cancer or successfully treated in situ carcinoma are eligible.
5) History of Human Immunodeficiency Virus (HIV) infection.
6) Certain cardiac abnormalities
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Progression free survival (PFS), defined as the time from randomization until the first date of either objective disease progression or death due to any cause. This will be determined according to the definitions established in the Response Evaluation Criteria in Solid Tumors (RECIST 1.1).[Approximately 2 years]
- Secondary Outcome Measures
Name Time Method