The effect of local and systemic administration of vitamin C on extraction wound healing: A clinical study

Phase 4

Recruiting

• Conditions: Wound healing of tooth extraction socket; Vitamin C; Local administration; Systemic administration; Tooth extraction; Wound healing

• Registration Number: TCTR20190828001
• Lead Sponsor: Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-28
• Study Completion: 2020-04-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1. Patients who have bilaterally symmetrical non-infected premolars needed for extraction such as extraction for orthodontic treatment
2. Age between 15 to 35 years
3. Patients who have American Society of Anesthesiologist (ASA) class I or II
4. No antibiotic usage
5. Simple/ atraumatic extraction

Exclusion Criteria

1. Infection is found at site of extraction
2. Smokers or alcoholics
3. On drug therapy which may affect wound healing such as glucocorticoid steroids and non-steroidal anti-inflammatory drugs
4. Pregnant woman, lactating women and patients who take estrogen-containing contraceptive drugs
5. Patients who have blood disorders like thalassemia, G6PD deficiency, sickle cell disease and hemochromatosis.
6. Psychiatric patients
7. Patients who cannot participate with the study and post-operative follow-up
8. Other vitamin consumptions
9. Patients who cannot take vitamin C at least 2 times/ day and miss to take vitamin C more than 4 times in the period of 14 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
soft tissue healing 7 days post-operation and 21 days post-operation The modified of Landry index,size of the sockets Immediately after extraction, 7 days post-operation and 21 days post-operation caliper and periodontal probe ,bone healing Immediately after extraction and 21 days post-operation computer software (ImageJ) ,bone healing Immediately after extraction and 21 days post-operation computer software (ImageJ)

Secondary Outcome Measures

Name	Time	Method
postoperative pain Postoperative day 1,2,3 visual analogue scale