Central Blood Pressure and Pulse Wave Velocity in Children With and Without Kidney Transplants
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Oscillometric central blood pressure
研究概览
简要总结
An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls. Using an oscillometric monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. The investigators will also enroll age- and race-matched healthy controls and measure the same parameters for comparison. In addition, the investigators will measure PWV by standard arterial tonometry method in a subset of patients.
详细描述
The specific aims of the study are as follows:
- Using an oscillometric blood pressure monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease.
- Measure oscillometric central blood pressure and PWV in age and race matched healthy children.
- Measure PWV by standard arterial tonometry method in a subset of patients, and compare these measurements to the PWV measured using the oscillometric device.
- Measure body composition of patients and controls (Body Mass Index, Waist-to-Height ratio, %body fat, and mid-arm muscle circumference) to see how this relates to central blood pressure and PWV.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •kidney transplant recipients who are at least 6 months post-transplant
- •healthy children matched for age sex and race
排除标准
- •age less than 3 years
结局指标
主要结局
Oscillometric central blood pressure
时间窗: cross-sectional measurement performed in patients who are between 6 months to 10 years post-transplant
Central blood pressure as measured by oscillometric blood pressure device
Oscillometric pulse wave velocity
时间窗: cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant
Pulse wave velocity as measured by oscillometric blood pressure device
次要结局
- Mid arm circumference (cm)(cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant)
- Body mass index (BMI) in kg/m2(cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant)
- Waist circumference (cm)(cross-sectional measurement performed in patients who are anywhere between 6 months to 10 years post-transplant)
研究者
Kristen Sgambat
Clinical Dietitian IV
Children's National Research Institute