An exploratory study to compare two different dosing pattern of internal oleation against conventional method -for the purpose of detoxification.

Phase 3

Conditions: Health Condition 1: J00-J99- Diseases of the respiratory systemHealth Condition 2: L00-L99- Diseases of the skin and subcutaneous tissueHealth Condition 3: M05-M14- Inflammatory polyarthropathiesHealth Condition 4: E70-E88- Metabolic disordersHealth Condition 5: E282- Polycystic ovarian syndromeHealth Condition 6: M45-M49- Spondylopathies

Registration Number: CTRI/2023/04/051263

Lead Sponsor: Department of Panchakarma Ayurvedic and Unani Tibbia college and hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1.All patients, irrespective of their disease getting admitted for vamana or virechana may be considered for this study.

2.Healthy volunteers willing to undergo vamana or virechana for wellness purpose.

3.Patients who are ready to give the written informed consent.

4.The trial subjects of any ongoing trial will be considered for conventional method group. No alteration will be made in their treatment protocol and only data will be collected from such participants. A separate consent will be taken from such participants.

Exclusion Criteria

1.Patients who are not fit for snehapana and shodhana karma.

2.Patients with uncontrolled high blood pressure ( >160/100 mm of Hg)

3.Patients who are diabetic having HbA1c more than 7.5%.

4.Patients who are diagnosed with malignancy of any system .

5.Patients who are immune compromised.

6.Pregnant and lactating women

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Achievement of samyaka lakshana of shodhanaartha snehapaan. (Vatanulomana, Deeptagni, Purisha snigdhta, Snehodvega, Vitta shaithilyam, Twaka snigdhta, Gatra mriduta, Glani, Anga laghavata, Adhastatsnehadarshana)Timepoint: On day 3, 4, 5, 6, 7, 8 and 9 by using a detailed format.

Secondary Outcome Measures

Name	Time	Method
Assessment of Ayoga, Atiyoga and Updadrava of abhyanatra snehapaana with each dosing pattern.Timepoint: Last day of snehapaana and upto samsarjana krama/ upto 10th day.;Assessment of Shodhana (Vamana / Virechana) achieved through three dosing patterns.Timepoint: On day 2nd/3rd (for vamana) and day 4th/5th (for virechana);Assessment of Sneha jeeryamana lakshana with each dosing pattern. (Shiroruja, Bhrama, Nishtheeva, Murchha, Saada, Arati, Klama, Trishna, Daha)Timepoint: On daily basis.;Assessment of Snehajeerana lakshana with each dosing pattern. (Vatanulomana, Swasthya, Kshudha, Trishna, Udgaara shudhhi, Laghuta, shiro rujaadi jeeryamana lakshana pashamana)Timepoint: On daily basis