Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

Not Applicable

Completed

• Conditions: Methicillin-resistant Staphylococcus Aureus
• Interventions: Drug: pharmacological decolonization treatment; Behavioral: Education

• Registration Number: NCT01232231
• Lead Sponsor: Joseph Kim

Brief Summary

The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07
• Study First Submitted: 2010-11-01
• Study First Submitted QC: 2010-11-01
• Study First Posted: 2010-11-02
• Primary Completion: 2012-04
• Study Completion: 2012-11
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-14
• Last Update Posted: 2013-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Prior MRSA infection (i.e index case)
• Identified as being colonized with MRSA on initial screen

Exclusion Criteria

• Are pregnant or breastfeeding.
• Have indwelling catheters.
• Received prior decolonization treatment within last 6 months of enrollment.
• Have allergy to study medication.
• Are colonized with MRSA strain resistant to study medication.
• Have active infection requiring systemic antimicrobials.
• Are household contacts to index case.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
decolonization treatment	pharmacological decolonization treatment	topical antiseptic, intranasal antimicrobial, and oral antimicrobial that have activity against MRSA in addition to education regarding personal hygiene and environmental cleaning
education	Education	No decolonization treatment in addition to education regarding personal hygiene and environmental cleaning

Primary Outcome Measures

Name	Time	Method
Eradication of MRSA carriage	90 days after randomization

Secondary Outcome Measures

Name	Time	Method
Occurrence of MRSA infection	Within 6 months of randomization

Trial Locations

Locations (1)

Foothills Medical Center; 🇨🇦 Calgary, Alberta, Canada