Overnight Feeding Study in Glycogen Storage Disease Type 1
- Conditions
- Glycogen Storage Disease Type 1 (GSD 1)
- Interventions
- Other: overnight nutrition regime
- Registration Number
- NCT01961076
- Lead Sponsor
- University of Zurich
- Brief Summary
In this clinical cross-over study, we will compare the efficacy of different oral nutrition regimens for night-time glucose control in adult GSD 1 patients. Three different over-night nutrition regimens (=interventions) will be compared in each patient sequentially, (1) uncooked corn starch (UCSS, "Maizena"), (2) modified corn-starch, (3) other carbohydrate (starch) containing meal. During each intervention, glucose profiles will be continuously monitored by continuous glucose monitoring (CGMS). The duration of each intervention is 3d (mimimum) to 6d (maximum), depending on the quality of night-time glucose control and the technical quality of glucose sensor readings. Between the interventions, the patients follow their normal prescribed diet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description uncooked corn starch overnight nutrition regime Patients receive uncooked corn starch before bed-time modified corn starch overnight nutrition regime Patients receive modified corn starch before bed-time other carbohydrate (starch) containing meal overnight nutrition regime Patients receive a carbohydrate (starch) containing meal before bed-time
- Primary Outcome Measures
Name Time Method Maximum fasting time over-night (h) Maximum fasting time will be measured during each dietary intervention for an average period of 3d (minimum) to 6d (maximum)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Zurich, Division of Endocrinology, Diabetes and Clinical Nutrition
🇨ðŸ‡Zurich, ZH, Switzerland