Estrogen and Gender Biased Autoimmunity
- Conditions
- Systemic Lupus Erythematosus
- Interventions
- Other: Peripheral lab draws
- Registration Number
- NCT00519454
- Lead Sponsor
- The Center for Rheumatic Disease, Allergy, & Immunology
- Brief Summary
This study involves research to investigate how estrogen affects women of childbearing age and its correlation to Systemic Lupus Erythematosus. The findings from this study might help determine how body cells, called T Cells, react to estrogen. The study will seek to determine if cells from women with Lupus, react differently from cells in persons without Lupus. We will attempt to identify genetic factors that determine the effects of estrogen on Lupus cells.
- Detailed Description
This is a 3-year study. The total number of subjects enrolled will depend on the results obtained. The subjects will be at least 18 years of age and pre-menopausal. Exclusion to include pregnant women, and all subjects are told not to get pregnant while on study. Also, they cannot take hormones by mouth or patch while on study. The study can include healthy subjects as well. Blood will be drawn (120 ml) four times a year, randomly.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 75
- female subjects with Lupus, and female subjects without Lupus. age at least 18, not pregnant and not planning to get pregnant.
- Pregnant or planning to get pregnant. On hormone replacement, or birth control of any kind.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Female Lupus patients Peripheral lab draws Females who are still childbearing age, not on hormones, with Systemic Lupus Erythematosus, still cycling.
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Center for Rheumatic Disease, Allergy and Immunology
🇺🇸Kansas City, Missouri, United States