Comparison the effects of memantine and sodium valproate in migraine pain prophylaxis
- Conditions
- Migraine.Migraine without aura
- Registration Number
- IRCT20180624040229N1
- Lead Sponsor
- Ardabil University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
A history of migraines based on the criteria of the international community of headache.
The number of headache attacks is more than three attacks per month.
Failure of prophylactic treatment with one or more migraine prevention drugs.
Any headache attack with more than 48 hours of analgesia should be distinguished from other attacks
Filling out the consent form of the Clinical trial
age 16 to 65
Other headache
Use of other migraine prevention medications
Drug dependence on drugs or alcohol
Renal dysfunction
Excessive use of acute migraine attack drugs (more than 8 days in the month of receiving ergots, NSAIDs or tryptans)
Sensitization to memantine or sodium valproate or their compounds.
Acute resistant migraine
Severe psychiatric disorders (bipolar disorder, mental disorder, severe depressive disorder, obsessive-compulsive disorder, or functional disorder, general anxiety disorder, Somatization)
Neurodegenerative disorders
malignancy , pain disorder, severe infection
Pregnant or Breastfeeding women
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Headache score by MIDAS score. Timepoint: At the beginning , 3 month later, 6 month later. Method of measurement: MIDAS score.
- Secondary Outcome Measures
Name Time Method