Discovering Novel Cancer Treatment Options Using a Comprehensive NGS-based Liquid Molecular Testing Panel in the Community Setting. ("DINOSAur II")
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Stage III Solid Tumors
- Sponsor
- Glendale Adventist Medical Center d/b/a Adventist Health Glendale
- Enrollment
- 572
- Locations
- 1
- Primary Endpoint
- European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (QLQ-C30)
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
To prospectively identify cancer patients whose tumors express specific molecular markers targeted by therapeutic agents from a comprehensive l i q u i d molecular test, for the purpose of selecting the most clinically appropriate treatment in a pragmatic two arm trial.
Investigators
Mihran Shirinian
Principal Investigator
Glendale Adventist Medical Center d/b/a Adventist Health Glendale
Eligibility Criteria
Inclusion Criteria
- •Patients who have given informed consent in accordance with the methods and procedures of this study
- •Diagnosis of cancer (stage 3 and stage 4; solid tumors only) requiring medical care
- •Patients who have not received treatment related to his/her cancer
- •Patients who are willing to sign a release of medical records to the research team
- •Male and female patients ≥18 years of age
- •Patients under oncology care
- •Sufficient clinical status for collection of blood sample within usual care
Exclusion Criteria
- •Patients considered minors in the jurisdiction where the protocol is conducted
- •Patients who are prisoners and pregnant women
- •Patients who cannot provide consent and did not sign a power of attorney
Outcomes
Primary Outcomes
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (QLQ-C30)
Time Frame: 2 years
The EORTC Core Questionnaire (QLQ-C30) includes six clearly distinguishable functioning scales that have been thoroughly tested and validated on an international level and that are available in 110 different language versions. The scaling of items is 1 (Not at all) to 4 (Very much), 1 (Very poor) to 7 (Excellent). The higher the score the better the quality of life.
Secondary Outcomes
- Compare the proportion of enrolling in clinical trials(2 years)