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Clinical Trials/NCT05901493
NCT05901493
Recruiting
Not Applicable

Improving the Retention of Speech-Perceptual Learning in Adults With and Without Language Disorder

University of Delaware2 sites in 1 country540 target enrollmentOctober 23, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Developmental Language Disorder
Sponsor
University of Delaware
Enrollment
540
Locations
2
Primary Endpoint
Speech discrimination - behavior
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

Approximately 7% of the population experiences developmental language disorder (DLD), a language disorder with unclear causes. DLD affects communication beyond adolescence and poses challenges for education and career advancement due to difficulties in learning and memory. Recent research suggests that adults with DLD struggle with overnight memory consolidation, indicating a need for effective learning and memory support. This project aims to determine the optimal training schedule for perceptual memory retention in adults with and without DLD. The study involves recruiting 240 adults (120 with DLD, 120 without) for speech-perceptual training with different training schedules. The researchers predict that the manipulation of training schedules will interact with circadian preference and overnight consolidation, leading to the discovery of the best practice schedule for speech sound retention. Additionally, 300 more adults (150 with DLD, 150 without) will be recruited to investigate how optimal training schedules interact with reflexive and reflective learning strategies. The time course of learning and retention will be tracked during reflexive and reflective categorization training in six different training schedules.

Detailed Description

Developmental language disorder (DLD) describes the idiopathic disorder(s) of language that occurs in approximately 7% of the population. Although DLD is understudied in adulthood, it is clear that the communication challenges in DLD extend beyond adolescence. The barriers to educational and vocational achievement for adults with DLD include persistent difficulties in learning and memory. Recent work suggests that these difficulties with learning and memory include deficits in overnight memory consolidation. Thus, an effective support for learning and memory function in adults with DLD must include strategies for both overcoming initial challenges in learning, as well as in mitigating a deficit in consolidation of learned information. In this project, the investigators combine insights from the neurobiology of learning and memory, chronobiology, and speech perception, to determine the optimal training schedule for perceptual memory retention in adults with and without DLD. The investigators have two Aims in this project: First, the investigators will recruit 240 adults (120 with/120 without DLD) to participate in a speech-perceptual training to take place in one of six different training schedules over 24 hours. The investigators predict that our manipulation of training schedules will interact with circadian preference and timing relative to overnight consolidation, to allow the discovery of the optimal practice schedule for speech sound retention for adult learners with \& without DLD. Under our second aim, the investigators will recruit an additional 300 adults (150 with/150 without DLD) in order to determine how optimal training schedules interact with reflexive and reflective learning strategies in adults with and without DLD. The investigators will achieve this aim by tracking the time course of learning and retention in adults participating in reflexive and reflective categorization training in one of six training schedules.

Registry
clinicaltrials.gov
Start Date
October 23, 2022
End Date
July 31, 2027
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • native speakers of American English
  • Grew up in a household in which only American English was spoken
  • 18-55 years of age
  • Typical vision \& hearing
  • (Aim 2) access to headphones/devices capable of accessing experiment script via internet
  • Must meet criteria for Group membership as either TD or DLD

Exclusion Criteria

  • History of neurological disorders
  • History of psychiatric disorders
  • History of socio-emotional disorders
  • On prescription medication(s) that alter sleep

Outcomes

Primary Outcomes

Speech discrimination - behavior

Time Frame: 1 week

Participants will be administered a short (approximately 4-minute) behavioral task. They will be exposed to two speech sounds, separated by a 1-second interval. Some sounds will begin with the dental stop consonant, and other sounds will begin with the retroflex stop consonant. Participants will be asked to decide if the two sounds they hear are the same or different. Accuracy will be converted to d-prime (a measure of signal detection). This d-prime score will be the primary behavioral outcome for speech discrimination.

category identification - behavior

Time Frame: 48 hours

Participants will be administered a short (approximately 2 minutes) for each modality (auditory and visual). Participants will either hear (auditory - pure tone) or see (visual - gabor patch) a stimulus, and will need to choose which category the stimulus belongs to out of a choice of two. The percentage of trials that are answered correctly will be the primary behavioral outcome for auditory and visual category identification.

Secondary Outcomes

  • Speech discrimination - Event-related potential of the electroencephalogram (ERP/EEG)(1 event-related potential (ERP) session 1 week following training)

Study Sites (2)

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