Symptom trajectories in patients with advanced chronic obstructive pulmonary disease (COPD) or lung cancer - a prospective longitudinal study

Recruiting

Conditions: C34
J44
Other chronic obstructive pulmonary disease
Malignant neoplasm of bronchus and lung

Registration Number: DRKS00000312

Lead Sponsor: Institut für Palliative Care (ipac) e.V.

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients with the following criteria will be eligible for this study.
The inclusion criteria will be:
1)diagnosis of advanced disease as defined as follows:
Lung cancer: Primary lung cancer at all stages (small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)), cancer at any site with secondary tumour of the lung (lung metastasis);
COPD: stage III or IV of the GOLD classification (Global Initiative for Obstructive Lung Disease), which include the airflow limitation measured by spirometry FEV1 < 50%, FEV1/FVC < 0.7 (FEV1: forced expiratory volume in one second; FVC: forced vital capacity) and symptoms such as more severe breathlessness, reduced exercise capacity and repeated exacerbations;
2)age = 18 years.
Disease orientated therapies (chemotherapy, radiotherapy, surgery) can be ongoing.

Exclusion Criteria

(1) lack of capacity to give informant consent; (2) lack of capacity to be interviewed;(3)cognitive impairment (clinical judgment by the principal investigator)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dyspnoea: modified Borg-Scale; episodic breathlessness: number of attacks, mean length of attack, severity of attack<br>Time of measurement: every 4 weeks

Secondary Outcome Measures

Name	Time	Method
symptoms and needs: Palliative Care Outcome Scale (POS); functional ability: Karnofsky Performance Scale (KPS); quality of life: EuroQoL5 (EQ-5D); health service use: number of hospital admissions, number of admissions to A&E; comorbidities: Charlson Comorbidity Index (CCI)