Using a Novel Functional MRI Technique to Evaluate for Neurotoxicity

Completed

• Conditions: Central Nervous System Lymphoma
• Interventions: Diagnostic Test: Resting State fMRI (rsfMRI); Other: Auditory Attention and Executive Functions Test; Other: Memory Test; Other: Motor Speed Test; Other: Self Reported Quality of Life Questionnaire

• Registration Number: NCT03342586
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this study is to test resting state functional Magnetic Resonance Imaging (rsfMRI) scans to see if rsfMRI scans are better than the standard task based fMRI scans at diagnosing or monitoring central nervous system lymphoma.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-07
• Study First Submitted: 2017-11-09
• Study First Submitted QC: 2017-11-13
• Study First Posted: 2017-11-17
• Status Verified: 2022-08
• Primary Completion: 2022-08-04
• Study Completion: 2022-08-04
• Last Update Submitted: 2022-08-04
• Last Update Posted: 2022-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Immunocompetent patients with newly diagnosed or recurrent non-Hodgkins lymphoma involving the brain (primary or secondary), as demonstrated by MRI and histologic confirmation either by positive CSF cytology for lymphoma or a monoclonal lymphocyte population defined by cell surface markers, vitreous or uvea biopsy or brain biopsy
• Age 18-80 years
• Treatment plan for HDC-ASCT
• Fluent in English
• Patients who in the judgment of the investigators and/or consenting professional, are able to understand the purpose of the study and provide informed consent will be included.

Exclusion Criteria

• Claustrophobia
• Any contraindication to the use of contrast and/or general guidelines for MR imaging as per standard Department of Radiology imaging guidelines
• Unable to cooperate for MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Central Nervous System Lymphoma	Motor Speed Test	Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)
Central Nervous System Lymphoma	Resting State fMRI (rsfMRI)	Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)
Central Nervous System Lymphoma	Auditory Attention and Executive Functions Test	Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)
Central Nervous System Lymphoma	Self Reported Quality of Life Questionnaire	Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)
Central Nervous System Lymphoma	Memory Test	Participants will have non-Hodgkins lymphoma involving the brain (primary or secondary)

Primary Outcome Measures

Name	Time	Method
Change in resting state brain networks over time in participants with central nervous system lymphoma before and after treatment with high-dose chemotherapy with autologous stem cell transplantation through resting state fMRI results	6 months

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States