Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.
- Conditions
- Jaundice
- Interventions
- Device: light treatment
- Registration Number
- NCT02224586
- Lead Sponsor
- Hangzhou Normal University
- Brief Summary
It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).
The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.
Doctors observe the status of infants aside.Using monitoring probe can see clearly.
- Detailed Description
resting state fMRI scan light therapy the second time resting state fMRI scan
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- hyperbilirubinemia
- asphyxia
- cerebral dysgenesis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description light treatment light treatment clinical routine treatment according to the doctor's advice
- Primary Outcome Measures
Name Time Method amplitude of low-frequency fluctuation change before and after light treatment before and after light treatment It is indicator of blood oxygenation level dependent.
- Secondary Outcome Measures
Name Time Method cerebral blood flow change before after light treatment before and after light treatment It is indicator of arterial spin labeling.
Trial Locations
- Locations (1)
Center for Cognition and Brain Disorders
🇨🇳Hangzhou, Zhejiang, China