Evaluation of the effectiveness of calcium hydroxide-based medications in root canal inflammatio

Not Applicable

• Conditions: K04.5; K04.1; Dental Pulp Necrosis; Chronic apical periodontitis; Periapical Abscess; Periapical Diseases; C07.793.237.315; C01.830.025.650; C07.320.830

• Registration Number: RBR-9xhgs6
• Lead Sponsor: niversidade Estadual Paulista Júlio de Mesquita Filho - Campus São José dos Campos

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-18
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients in adulthood;
Need for endodontic treatment;
Permanent teeth with primary endodontic infection;
Unirradicular;
Presence of a single canal and periapical lesion;
Absence of periodontal pockets greater than 4 mm;
No mobility.

Exclusion Criteria

Teeth that can not be insulated with the rubber dam;
With root fracture;
Exposure of the pulp chamber;
Patients who have used antibiotics or antifungals in the last 3 months;
Patients with systemic disease.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1-Reduction of matrix metalloproteinases (MMP-1, MMP-2, MMP-9) with resolution or significant reduction of the periapical inflammatory process, verified by means of the Immunoenzymatic Assay (ELISA) method, which allows the detection of amounts of protein nanograms (10-9 g) from the observation of a variation of at least 5% in the pre- and post-intervention measurements.

Secondary Outcome Measures

Name	Time	Method
Expected outcome 1-Increased release of tissue inhibitors of matrix metalloproteinase metalloproteinases (TIMP-1, TIMP-2) with resolution or significant reduction of the periapical inflammatory process, verified through the immunoenzymatic assay method (ELISA), which allows the detection of quantities of protein of the order of nanograms (10-9 g) from the observation of a variation of at least 5% in the pre and post-intervention measurements.