Examination of the Effect of Antibiotics on Inflammatory Factors in Neonates

Not Applicable

• Conditions: Bacterial sepsis of newborn.; Bacterial sepsis of newborn

• Registration Number: IRCT201504289568N13
• Lead Sponsor: Shahed university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All healthy full-term babies, having healthy mothers and normal Apgar scores, suspected of sepsis and candidates for antibiotic treatment in the NICU of Vali-e Asr Hospital.
Exclusion criteria: Infants with positive blood cultures, infants with positive cerebrospinal fluid culture, infants being treated with corticosteroids, infants whose mothers were treated with corticosteroids or magnesium sulphate at least one week prior to delivery, infants whose mothers received antibiotics prior to delivery, cord acidosis and birth asphyxia, infants that are intravenously fed, and infants of ill mothers.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IL-1ß. Timepoint: just before and 12 hrs after intervention. Method of measurement: ELISA,pg/ml.;IL-6. Timepoint: just before and 12 hrs after intervention. Method of measurement: ELISA,pg/ml.;IL-8. Timepoint: just before and 12 hrs after intervention. Method of measurement: ELISA,pg/ml.;TNF-a. Timepoint: just before and 12 hrs after intervention. Method of measurement: ELISA,pg/ml.