Influence of Therapeutic Hypothermia on Resting Energy Expenditure

Completed

• Conditions: Cardiopulmonary Resuscitation
• Interventions: Procedure: Measurement of Resting Energy Expenditure

• Registration Number: NCT00500825
• Lead Sponsor: Medical University of Vienna

Brief Summary

The purpose of this study is the evaluation of the influence of therapeutic hypothermia on resting energy expenditure (REE) in patients after cardiopulmonary resuscitation (CPR). We hypothesized that hypothermia would reduce resting energy expenditure in these patients.

Detailed Description

Therapeutic hypothermia improves neurologic outcome in patients after cardiopulmonary resuscitation (CPR) because of cardiac arrest. In the present study patients will be cooled to 33 degree Celsius after CPR for 24h. To avoid shivering patients will be analgosedated and medically paralysed. Analgosedation and relaxation have already shown to reduce oxygen consumption up to 20 % in critically ill patients.

In patients with brain injury, who were cooled to 33 degree Celsius using a cooling meadow REE could be significantly reduced. In critically ill patients with pyrexia cooling using a cooling meadow REE could be reduced. Oxygen consumption was reduced about 14,7% per degree Celsius.

So far no studies evaluating influence of therapeutic hypothermia on REE in patients after CPR have been published. Therefore we plan to measure REE in 25 cooled patients after CPR using indirect Calorimetry (Deltatrac II Metabolic Monitor, Datex Instrumentarium, Helsinki, Finland).

Study Timeline

• Study Start: 2005-07
• Study First Submitted: 2007-07-11
• Study First Submitted QC: 2007-07-11
• Study First Posted: 2007-07-13
• Primary Completion: 2008-03
• Status Verified: 2008-05
• Study Completion: 2008-05
• Last Update Submitted: 2008-05-15
• Last Update Posted: 2008-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• St.p. CPR
• Indication for therapeutic hypothermia for 24h (33 degrees Celsius)

Exclusion Criteria

• Contraindication for therapeutic hypothermia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Measurement of Resting Energy Expenditure	Patients successfully resuscitated after cardiac arrest undergoing therapeutic hypothermia

Trial Locations

Locations (1)

Medical University Vienna; 🇦🇹 Vienna, Austria