A Comparison of Balanced Salt Solution Vs. Normal Saline in Major Abdominal Surgery.
Phase 4
Completed
- Conditions
- Health Condition 1: null- Adult ASA physical status I- III patients presenting for elective open abdominal surgery under General Anesthesia at PGIMER.
- Registration Number
- CTRI/2018/06/014483
- Lead Sponsor
- Shilpa Joshiya
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 113
Inclusion Criteria
Adult ASA physical status I-III patients presenting for elective open abdominal surgery under GA at PGIMER, Chandigarh.
Exclusion Criteria
Patients with pre-existing renal dysfunction (Sr. creatinine > 1.5mg/dl), those with abnormal sodium, potassium, chloride levels on pre-operative biochemistry screen, resting elevations of PaCO2, known clinical lung disease, H/O congestive heart failure or pulmonary hypertension, pre-operative use of diuretic or steroid replacement therapy, Hb <7gm/dl and those refusing consent were excluded from study participation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in chloride concentration of less than 3 mEq/L between the plasmalyte and normal saline groups at the end of surgery with restrictive fluid regimen.Timepoint: Difference in chloride concentration of less then 3 mEq/
- Secondary Outcome Measures
Name Time Method Acidosis at first post operative day .Timepoint: pH less than 7.35;decreased urine output with restrictive regimen leading to risk of renal injuryTimepoint: urine output less than 0.5ml/kg/hr . <br/ ><br>risk of renal injury by RIFLE criteria.