Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome.

Completed

• Conditions: Hypermobile Ehlers-Danlos Syndrome

• Registration Number: NCT05000151
• Lead Sponsor: Hakimi Adrien

Brief Summary

Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to healthy subjects, and whether a cognitive task can influence ventilation control differently in subjects with hEDS than in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-07-30
• Study First Submitted QC: 2021-08-07
• Study First Posted: 2021-08-11
• Study Start: 2021-09-02
• Primary Completion: 2022-05-19
• Study Completion: 2022-05-19
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-21
• Last Update Posted: 2022-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 38

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy of lung volume perception	Baseline	The perception of lung volume is assessed using a device comprising a flow meter, an electronic acquisition card and an LCD screen. Subjects will be given 3 trials to train to perceive a target lung volume and then 3 trials without feedback to reproduce that target lung volume. The mean of the absolute deviations from the target volumes in percent is used as the primary outcome.

Secondary Outcome Measures

Name	Time	Method
Respiratory rate variability	Baseline	The time interval between each inspiratory peak will be recorded and will allow the calculation of the standard deviation and the root mean square with and without the cognitive task.
Minute ventilation with or without cognitive task	Baseline	The minute ventilation will be calculated over 1 minute without cognitive task and then over 1 minute with cognitive task (trail making test part B).

Trial Locations

Locations (1)

Clinique de la Mitterie; 🇫🇷 Lomme, France