Behavioral and psychological characteristics of children with narcolepsy

Recruiting

• Conditions: Narcolepsy; 10040998

• Registration Number: NL-OMON40494
• Lead Sponsor: Epilepsiecentrum Kempenhaeghe

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 95

Inclusion Criteria

Narcolepsy:
- Children with the diagnoses of narcolepsy according to the ICSD-2 criteria (both with and without cataplexy);- Due to age restrictions of the various instruments, children from 7 to 16 years old will be included in this study. For children who are diagnosed with narcolepsy during the course of the study and will participate as 'new diagnosis', an upper limit of 15 years has to be maintained. This is related to the age restriction of the WISC III NL;- Under treatment at one of the participating centers (ie Kempenhaeghe, UZ Gent, MC Haaglanden and LUMC);Juvenile idiopathic arthritis:;- Children with a diagnosis of juvenile idiopathic arthritis according to ILAR classification
- Children between the ages of 7 to 16 years
- At least one year under the supervision of a specialist
- Minimal treatment with NSAIDs and MTX;Healthy controls:;- Children between the ages of 7 to 16 years
- No medical diagnosis / treatment

Exclusion Criteria

For both clinical groups and healthy controls:;- - Intellectual disability of the child (IQ <70)
- Intellectual disability of either parent (s) / guardian (s) (IQ <70)
- Problems with command of the Dutch language by the child
- Problems with command of the Dutch language by both parent (s) / guardian (s);Additional for healthy controls:
- A medical diagnosis requiring active treatment

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Given the exploratory nature of the study, there are several primary study<br /><br>parameters. Regarding the personality there is particular interest in the<br /><br>dimensions: 'extraversion' and 'emotional stability'. These are obtained from<br /><br>the Hierarchical personality questionnaire for children (HIPIC) and the<br /><br>Dimensional Personality Symptom Item Pool (DiPSI) and serve as the primary<br /><br>study parameter for personality traits. Social behavior is measured by the<br /><br>subscale 'autistic behaviors' obtained from the Social Emotional Questionnaire<br /><br>(SEV). The overall IQ score obtained from the Wechsler Intelligence Scale<br /><br>(WISC-III-NL) is chosen as the primary parameter for intellectual functioning.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures include 'internalizing' from the Child Behavior<br />Checklist (CBCL) and the total score of the Child Depression Inventory (CDI).</p>