The Impact of Insulin Pump Therapy to Oxidative Stress in Patients With Diabetic Nephropathy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Insulin Pump Therapy in Treating Diabetic Nephropathy
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 160
- Primary Endpoint
- The change of 8-hydroxy-deoxyguanosine (8-OHdG)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The recent study suggested that oxidative stress resulting from increased production of reactive oxygen species (ROS) plays a crucial role in the development of diabetic complications. The researches aim to monitor the level of oxidative stress of patient in different stage of diabetic nephropathy before and after insulin pump therapy.
Detailed Description
Worldwidely, about 30% of Type 1 Diabetes Mellitus (T1DM) and 20%-50% of T2DM patients suffered diabetic nephropathy (DN). Oxidative stress resulting from increased production of reactive oxygen species (ROS) plays a crucial role in the development of diabetic complications. Insulin pump therapy is better than subcutaneous injection in terms of the drug safety and effectiveness. The researches aim to monitor the level of oxidative stress of patient in different stage of diabetic nephropathy before and after insulin pump therapy.
Investigators
Xiaofeng Lv
Principal investigator
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •Diabetic patients with fasting plasma glucose (FPG) ≥10mmol/l and/or 2 hours' plasma glucose (2hPG) ≥15mmol/l.
Exclusion Criteria
- •Diabetic patients who
- •using antioxidant drugs within one month;
- •accompanied with acute and chronic severe complications, fever, malignant tumor, nephritis, congestive heart failure.
- •accompanied with diabetic ketosis, ketoacidosis, severe hypoglycemia, hyperosmolar hyperglycemic state;
- •with other endocrine diseases, autoimmune diseases, or connective tissue diseases;
- •having history of infection within 1 month;
- •having drug or alcohol dependence;
- •severe hypoxia and stress state (e.g., cardiovascular events, trauma, surgery, and consumptive disease, etc.)
Outcomes
Primary Outcomes
The change of 8-hydroxy-deoxyguanosine (8-OHdG)
Time Frame: 2 weeks
The change of 8-hydroxy-deoxyguanosine (8-OHdG) in serum of diabetic patients with diabetic nephropathy (DN)
Secondary Outcomes
- The change of glutathione (GSH)(2 weeks)
- The change of 3-nitrotyrosine (3-NT)(2 weeks)
- The change of superoxide dismutase (SOD)(2 weeks)