GRACE (Genomics to combat resistance against antibiotics in community acquired lower respiratory tract infections in Europe) WP10: Antibiotic Trial One - GRACE, wp10

niversity of Southampton0 个研究点目标入组 3,000 人开始时间: 2009年12月4日最近更新: 2017年4月3日

适应症

试验速览

暂无简介。

•Age 18 years to 59 years and 60 years and over (enrolment will be done in such a way with the aim to include 1500 patients under 60 and 1500 patients of 60 years and older)
•Consultation with acute cough as the main symptom (up to and including 28 days duration) or those in whom the general practitioner suspects the presence of acute lower respiratory tract infection
•Immuno-competent subject (no serious immunological deficiencies)
•Consultation for the first time within this illness episode
•Ability to fill out study materials
•Subject provided written, informed consent to participate
•Subject has not been included earlier in the current GRACE trial, either as a case or a patient
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Patients who have had antibiotics in the previous month
•Patients who are unable to properly consent or fill out the diary (dementia, psychosis, severe depression)
•Patients who are pregnant
•Allergy to penicillin or contra-indication for amoxicillin because of a major interaction with other medication
•community acquired pneumonia in history or found during physical examination i.e. new focal chest signs (focal crepitations or bronchial breathing) plus systemic features (high fever, vomiting, severe diarrhoea) - clinically diagnosed CAP on ethical grounds (practitioners would be very unlikely to be willing to randomise patients with CAP).

发起方

niversity of Southampton