ocal Application of Pilocarpine for Relieving Dry Mouth Complaints: A randomized controlled pilot trial
- Conditions
- mond, keelholtedry mouthxerostomia
- Registration Number
- NL-OMON48076
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
• >= 70 years of age;• Clinical diagnosis of chronic dry mouth defined as a Numeric Rating Scale (NRS) score >= 5 (scale 0 - 10, with 0 = no dry mouth and 10= worst possible dry mouth) on severity of xerostomia for more than 3 months.
• Existence of cognitive impairment and/or diagnosis of dementia appraised by treating physician ;• Inability to fill out the questionnaires due to other reasons;• Prior radiation therapy of the head-and-neck region;• Known m. Sjögren disease;• Contra-indications for parasympathicomimetics (uncontrolled asthma, acute heart failure, active peptic ulceration, known hypersensitivity to pilocarpine, and when miosis is undesirable, e.g., in acute iritis and in narrow-angle (angle closure) glaucoma.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in xerostomia score<br /><br>Change in oral health-related quality of life </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Adverse effects<br /><br>- Other symptoms<br /><br>- Global perceived effect</p><br>