Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
- Conditions
- Atrial FibrillationHeart FailureHeart; Dysfunction Postoperative, Cardiac SurgeryGenetic Predisposition to DiseaseMyocardial Infarction
- Registration Number
- NCT01258231
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.
- Detailed Description
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure. In addition, we also examine blood and urine biomarkers (proteins).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 4000
- Undergoing heart surgery
- Willing to provide consent
- Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality (i.e. number of participants who are deceased during postoperative day 0 up to year 5) Day of procedure to year 5 Data will be collected from electronic medical records; data points to be collected for this measurement include serum creatinine.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Department Texas Heart Institute at St. Luke's Episcopal Hospital
🇺🇸Houston, Texas, United States