The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population

Completed

• Conditions: Heart Attack
• Interventions: Genetic: DNA analysis

• Registration Number: NCT05090618
• Lead Sponsor: Asfendiyarov Kazakh National Medical University

Brief Summary

This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with heart attack

Detailed Description

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Study Timeline

• Study First Submitted: 2021-09-25
• Study First Submitted QC: 2021-10-21
• Study Start: 2021-10-23
• Study First Posted: 2021-10-25
• Primary Completion: 2023-01-20
• Study Completion: 2023-01-20
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-13
• Last Update Posted: 2023-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Persons of Kazakh nationality
• Age up to 59 years inclusive at the time of primary myocardial infarction
• Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography
• Presence of coronary angiography
• Persons able and willing to provide written informed consent;

Exclusion Criteria

• Age at primary myocardial infarction 60 years and older
• Heart defects, congenital and acquired
• Non-ischemic cardiomyopathies
• Autoimmune diseases
• Diabetes mellitus at the time of development of primary myocardial infarction
• Terminal stages of renal and hepatic failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	DNA analysis	Patients without Heart Attack
Experimental group:	DNA analysis	Patients with Heart Attack

Primary Outcome Measures

Name	Time	Method
number of SNPs associated with Heart Attack	1 year	Using GWAS to identify candidate genes associate with Heart Attack

Trial Locations

Locations (1)

Kazakhstan; 🇰🇿 Almaty, Kazakhstan