The Role of Genetic Factors in the Development of Atopic Dermatitis in the Kazakh Population

Completed

• Conditions: Atopic Dermatitis
• Interventions: Genetic: DNA analysis

• Registration Number: NCT05090631
• Lead Sponsor: Asfendiyarov Kazakh National Medical University

Brief Summary

This is a GWAS study that aims to identify possible candidate genes associate to atopic dermatitisby exploring single nucleotide polymorphism (SNP) in a group of atopic dermatitis, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with atopic dermatitis

Detailed Description

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Study Timeline

• Study First Submitted: 2021-09-25
• Study First Submitted QC: 2021-10-21
• Study Start: 2021-10-23
• Study First Posted: 2021-10-25
• Primary Completion: 2023-01-20
• Study Completion: 2023-01-20
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-13
• Last Update Posted: 2023-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Persons with various forms of a confirmed diagnosis of atopic dermatitis;
• The age of the patients is from 18 to 45+ years;
• Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
• Persons who are able and willing to provide written informed consent;
• Persons capable and willing to comply with the research protocol;

Exclusion Criteria

• Persons under the age of 18;
• Patients with severe concomitant systemic diseases, including cardiovascular, respiratory, hepatic and renal failure
• Patients with severe infectious processes (sepsis, abscess, hepatitis B and C, HIV)
• Persons with mental illness.
• Persons taking corticosteroid drugs, immunosuppressants within the last month;
• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Experimental group:	DNA analysis	Patients with atopic dermatitis
Control group	DNA analysis	Patients without atopic dermatitis

Primary Outcome Measures

Name	Time	Method
number of SNPs associated with atopic dermatitis	1 year	Using GWAS to identify candidate genes associate with atopic dermatitis

Trial Locations

Locations (1)

Kazakhstan; 🇰🇿 Almaty, Kazakhstan