Assessment of Renal Function in Cirrhotic Patients

• Conditions: Liver Failure; Renal Failure

• Registration Number: NCT01895114
• Lead Sponsor: Baylor Research Institute

Brief Summary

The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.

Detailed Description

Serum cystatin C, creatinine clearance based calculations, and 125I-Iothalamate clearance (Glofil) will be obtained in 220 patients with cirrhosis. Utilizing this information, the correlation between cystatin C and 125I-Iothalamate clearance will be obtained. In addition, the current serum creatinine based calculations and true creatinine clearance will also be correlated with 125I-Iothalamate clearance. The results of this study should help to determine whether serum cystatin C is a more sensitive laboratory measurement of renal function in patients with cirrhosis.

Study Timeline

• Study Start: 2010-12
• Study First Submitted: 2013-02-11
• Study First Submitted QC: 2013-07-05
• Study First Posted: 2013-07-10
• Status Verified: 2015-07
• Last Update Submitted: 2015-07-27
• Last Update Posted: 2015-07-28
• Primary Completion: 2015-12
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• over 18 undergoing evaluation for a liver transplant

Exclusion Criteria

• known allergy or sensitivity to 125I-Iothalamate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creatinine based blood and urine laboratory tests as a measure of renal function in patients with chirrosis of the liver.	24 hours

Trial Locations

Locations (1)

Baylor All Saint's Medical Center in Fort Worth; 🇺🇸 Fort Worth, Texas, United States