Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 1,901
- Primary Endpoint
- Clinical Pregnancy
Study Overview
Brief Summary
At which deleterious cut off value of progesterone on day of HCG (P-hCG) in our IVF program should fresh embryo transfer (ET) be cancelled?
Detailed Description
There is still an ongoing debate on the effect of subtle increased P-hCG concentration on pregnancy outcome after fresh ET. No consensus on the cut-off value to define increased P-hCG seems to exist. It is accepted that high P advances endometrium, leading to asynchrony between the implanting embryo and the endometrium, and resulting in implantation failure. A freeze all embryos policy and postponement of ET in subsequent frozen-thawed cycle has been proposed.
Study Design
- Study Type
- Observational
- Observational Model
- Case Crossover
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 49 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Fresh embryo transfer
- •Progesterone value on day HCG (Human choriogonadotrophin hormone)
Exclusion Criteria
- •Clinical indication for delaying embryo transfer
Outcomes
Primary Outcomes
Clinical Pregnancy
Time Frame: 6 weeks after embryo transfer procedure
Secondary Outcomes
No secondary outcomes reported
Investigators
Dr. Francisca Martínez
PhD
Institut Universitari Dexeus