Changes of Effective Downstream Pressure (EDP) and Cerebral Perfusion Pressure (CPP) under influence of hypnotics and volatile narcotics. A prospective, randomised, double-blinded trial.

Recruiting

• Conditions: cerebraal-vasculaire vaatweerstand, autoregulatie hersenen; blood pressure; brain perfusion; cerebral effective dowstream pressure

• Registration Number: NL-OMON29763
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 96

Inclusion Criteria

- Patients planed for surgical produre in general anaesthesia
- no intracranial surgery
- written informed consent
- 18 to 60 years old
- physical status ASA 1-2
- no history of cerebral illnes or cebrebrovascular deseases
- no medication with vasoactive therapeutics
(betabloker, alphabloker, nitrates, molsidomine, ACE-inhibitors, Ca-Antagonist,
diuretics)

Exclusion Criteria

- any cerebrovascular disease in history
- any history of cerebrovascular spasm
- any brain trauma in history
- any intracrainial neoplasma/tumor in history
- patients who cannot comunicate in Dutch or English language

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- EDP</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- CPPedp (mmHg)<br /><br>- Autoregulation phase relation between Vmca and the arterial pressure curve,<br /><br>(ms)<br /><br>- Difference between EDC calculation (Belford et al.) (mmHg)<br /><br>and instantanious EDP measurement (Weyland et al.) (mmHg) </p><br>