NCT03526666已完成不适用
Collection of Peripheral Blood From Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Chronic Myelomonocytic Leukemia for Measuring Baseline Ascorbic Acid Levels and Future Epigenetic Cancer Research
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Peripheral blood ascorbic acid levels
研究概览
简要总结
This study is a non-interventional, specimen collection translational study to evaluate vitamin C levels in the peripheral blood of Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), or Chronic Myelomonocytic Leukemia (CMML) patients.
详细描述
It has previously been established that hematological cancer patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) often exhibit severe vitamin C deficiency from a cohort of patients in Copenhagen. In this study, the investigators aim to determine if those results are conserved in another population/geographical location.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients actively receiving treatment for acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or chronic myelomonocytic leukemia (CMML).
- •Patients diagnosed with AML, MDS, or CMML and are treatment naïve.
- •Patients who are 18 years old or older.
排除标准
- •Patients deemed as too ill to participate as determined by the clinical investigator.
- •Non-English speaking patients
- •Patients unable to provide informed consent.
结局指标
主要结局
Peripheral blood ascorbic acid levels
时间窗: 1 year
The level of ascorbic acid
次要结局
- Evaluation of 5-methylcitosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) levels(1 year)
- Evaluation of human endogenous retroviral sequences (HERVs) expression(1 year)
研究者
Peter Jones
Cheif Scientific Officer
Van Andel Research Institute
研究点 (2)
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