Peripheral Nerve Ultrasound for Diagnosis and Prognosis of Guillain-Barre Syndrome: A Pilot Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Guillain-Barre Syndrome
- Sponsor
- Duke University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Internerve Variability of Cross-sectional Area (CSA) in Patients With GBS vs Controls
- Status
- Terminated
- Last Updated
- 11 months ago
Overview
Brief Summary
The purpose of this study is to determine if peripheral nerve ultrasound can be used as a supplemental tool to diagnose Guillain-Barre syndrome (GBS) in the acute setting and aid in prognostication.
Investigators
Eligibility Criteria
Inclusion Criteria
- •For GBS group: Inpatients with acute, progressive weakness and no alternative diagnosis, with onset less than 30 days prior to examination.
- •For control group: Hospitalized patients on the inpatient neurology service who are being treated for non-peripheral nerve disorders (e.g. epilepsy, multiple sclerosis, or stroke).
- •For all subjects: 18+ years of age
Exclusion Criteria
- •Patients with any history of multifocal motor neuropathy (MMN), prior Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), or hereditary neuropathy (e.g. Charcot-Marie-Tooth)
Outcomes
Primary Outcomes
Internerve Variability of Cross-sectional Area (CSA) in Patients With GBS vs Controls
Time Frame: Day 0 and approximately 7 days after admission
Internerve CSA variability for each patient will be calculated as: maximal intranerve CSA variability/minimal intranerve CSA variability. Intranerve CSA variability for each nerve will be calculated as: maximal CSA/minimal CSA for median and ulnar nerves.
Median Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls
Time Frame: Day 0 and approximately 7 days after admission
Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis.
Ulnar Nerve Intranerve Cross-sectional Area (CSA) Variability in Patients With GBS vs Controls
Time Frame: Day 0 and approximately 7 days after admission
Intranerve CSA variability for each nerve is calculated as: maximal intranerve CSA/minimal intranerve CSA . When both left and right ulnar nerves were scanned, the side with the largest intranerve CSA variability was used for analysis.
Secondary Outcomes
- Length of Hospital Stay in Days(Up to approximately 20 days)
- Ambulatory Status on Discharge(At discharge, up to approximately 20 days)
- Respiratory Dysfunction, as Measured by Number of Days Intubated(During admission, up to approximately 20 days)
- Strength, as Measured by Hand Dynamometer(Day 0, Day 7)
- Strength, as Measured by Medical Research Council (MRC)(Day 0, Day 7)
- Number of Participants With Autonomic Dysfunction(During hospitalization, up to approximately 20 days)
- Disability as Measured by the Guillain-Barre Syndrome (GBS) Disability Score(Day 0, Day 7, Discharge (up to approximately 20 days), Day 90, Day 180)