Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery
Completed
- Conditions
- GenotypeCognitive Impairment
- Interventions
- Genetic: Genotyping
- Registration Number
- NCT01088100
- Lead Sponsor
- Herlev Hospital
- Brief Summary
The purpose of this study is to determine whether a certain clock-gene (HPER3) with the 5/5 genotype carries a higher risk of post-operative cognitive dysfunction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 279
Inclusion Criteria
- patients undergoing non-cardiac and non-neurological surgery in either regional or general anesthesia
Exclusion Criteria
- daily use of major tranquilizers or antipsychotic medication
- known disease of the CNS
- score less than 24/30 points in MMSE
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients without POCD - controls Genotyping Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex. Patients with POCD - cases Genotyping Out of the 976 patients included in the ISPOCD2 study (Abildstrom H, Christiansen M et al. Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery. Anesthesiology 2004;101:855-61) the 93 patients with POCD whose blood samples are stored will be included together with 2x93 controls (without POCD), who will be matched by type of surgery, age, education, ASA-score and sex.
- Primary Outcome Measures
Name Time Method HPER3 genotype 3 months
- Secondary Outcome Measures
Name Time Method Post-operative morbidity ½ year
Trial Locations
- Locations (1)
Herlev Hospital - Gastro unit
🇩🇰Herlev, Denmark