Does Low-Dose Xenon Reduce Opioid Requirement and Postoperative Pain in Patients Undergoing Major Abdominal Surgery? A Randomized Controlled Trial

Phase 2

• Conditions: R52; Pain, not elsewhere classified

• Registration Number: DRKS00000597
• Lead Sponsor: Klinik für AnästhesiologieUniversitätsklinkum Ulm

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

ASA physical status I and II (NYHA = 1), patients scheduled for elective abdominal hysterectomy at the University Hospital of Ulm

Exclusion Criteria

Excusion criteria are respiratory tract infections, obstructive sleep apnea, diabetes mellitus, any relevant renal, liver, or heart (including arterial hypertension) disease, a history of neurological or psychiatric disorders or of adverse reactions to anesthetics, gastroesophageal reflux disease, regular alcohol consumption, drug abuse or taking sedatives or long acting analgesic drugs.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intra- and postoperative opioid requirement (remifentanil, morphine); patients subjective feeling of pain assessed 0.5, 3, 6, 12, and 24h postoperative using the well known numeric rating scale (NRS).

Secondary Outcome Measures

Name	Time	Method
relevant side-effects (e.g. vomiting, increased sedation), economical aspects (e.g. xenon/opioid consumption)