Home Bicycle Exercise and Aerobic Capacity

Phase 4

Completed

• Conditions: Metabolic Cardiovascular Syndrome
• Interventions: Behavioral: bicycle exercise

• Registration Number: NCT02268292
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

The subjects with MetS or type 2 diabetes were enrolled for this exercise-training program. All participators underwent an indoor bicycle exercise for twelve weeks. In addition to demographic data and biochemical tests were determined after an overnight fasting. Extension of muscle strength was detected in the dominant lower extremity.

Detailed Description

This prospective open-labeled study was conducted in Taichung Veterans General Hospital. The adult participants with metabolic syndrome and/or type 2 diabetes were enrolled. MetS. The procedures were fully explained to all subjects before the cardiopulmonary exercise test. ll enrolled subjects received a scheduled twelve-week program for exercise-training program. A commercially available bicycle with an indoor bicycle trainer are used as the home exercise training modality. All medications were not allowed to be changed during the study.

Study Timeline

• Study Start: 2012-08
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Study First Submitted: 2014-09-27
• Status Verified: 2014-10
• Study First Submitted QC: 2014-10-15
• Last Update Submitted: 2014-10-15
• Study First Posted: 2014-10-20
• Last Update Posted: 2014-10-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Adult with metabolic syndrome or type 2 diabetes

Exclusion Criteria

• hyperglycemic crisis or HbA1c > 12%;
• serum creatinine levels greater than 200 mmol/L;
• acute or chronic infectious diseases;
• limitations in the ability to undertake regular exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Bicycle Exercise	bicycle exercise	Bicycle Exercise for 12 weeks

Primary Outcome Measures

Name	Time	Method
Metabolic syndrome	12 weeks	Components of metabolic syndrome based on the modified Third Report of the National Cholesterol Education Program (NCEP) criteria

Secondary Outcome Measures

Name	Time	Method
Brain-derived neurotrophic factor	12 weeks	Serum concentration of Brain-derived neurotrophic factor (enzyme immunoassay method, R\&D Systems, Minneapolis, U.S.A.)
Arterial stiffness	12 weeks	Pulse wave velocity
Muscle strength	12 weeks	A Biodex Isokinetic Dynamometer (Biodex Medical Systems, Inc., Shirley, New York, USA) was used to evaluate the muscle strength of the subjects