Efficacy and Safety of Adalimumab in Patients With Rheumatoid Arthritis in Routine Clinical Practice
- Conditions
- Rheumatoid Arthritis
- Registration Number
- NCT01077258
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Brief Summary
Observation of safety, tolerability and effectiveness of adalimumab (Humira) therapy in a large patient collective under everyday clinical conditions over 2 years.
- Detailed Description
Patients with rheumatoid arthritis who started treatment with adalimumab in a normal clinical setting according to the product label were documented. The follow-up observation period was for 2 years and focused on safety information and maintenance of efficacy during a normal clinical setting. Follow-up with participants was via regular office visits at intervals as determined by routine clinical practice or as recommended by national guidelines.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 4208
- Moderate to severe active rheumatoid arthritis in adults with insufficient response to disease-modifying antirheumatic drugs, including methotrexate
- Moderate to severe active rheumatoid arthritis in adults who have not been treated with methotrexate before. In case of incompatibility with methotrexate, Humira can be used as monotherapy
- Hypersensitivity against the drug or one of the other ingredients
- Active tuberculosis or other severe infections (e.g. sepsis and opportunistic infections)
- Moderate to severe cardiac insufficiency
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change From Baseline in Disease Activity Score (DAS) 28 Baseline and Months 3, 6, 9, 12, 18, and 24 The Disease Activity Score 28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR), and the patient's assessment of global disease activity (on a visual analog scale \[VAS\] from 0 to 10 cm) are included in the DAS28 score. If the ESR value is missing, the C-reactive protein (CRP) value can be substituted. Scores on the DAS28 range from 0 to 10; higher scores indicate more disease activity. A DAS28 score \>5.1 indicates high disease activity, a DAS28 score \<3.2 indicates low disease activity, and a DAS28 score \<2.6 indicates clinical remission.
Percentage of Participants in DAS28 Remission Months 3, 6, 9, 12, 18, and 24 Clinical remission is defined as a disease activity score (DAS) 28 score of \< 2.6. The DAS28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR), and the patient's assessment of global disease activity (assessed on a visual analog scale \[VAS\] from 0 to 10 cm) are included in the DAS28. If the ESR value is missing, the C-reactive protein (CRP) value can be substituted. Scores on the DAS28 range from 0 to 10; higher scores indicate more disease activity.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With a Significant Therapeutic Response Baseline and Months 3, 6, 9, 12, 18, and 24 Significant therapeutic response was determined by DAS28 critical difference (Dcrit). A Dcrit response is a statistically determined value that exceeds the threshold of random fluctuation and signifies a positive individual response during treatment. A DAS28-Dcrit individual therapeutic response is defined as a decrease (improvement) in DAS28 from Baseline of ≥ 1.8.
The DAS28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR), and the patient's assessment of global disease activity (assessed on a visual analog scale \[VAS\] from 0 to 10 cm) are included in the DAS28. If the ESR value is missing, the C-reactive protein (CRP) value can be substituted. Scores on the DAS28 range from 0 to 10; higher scores indicate more disease activity.Percentage of Participants With Low, Moderate and High Disease Activity Baseline and Months 3, 6, 9, 12, 18, and 24 The DAS28 is a validated index of rheumatoid arthritis disease activity. Twenty-eight tender joint counts, 28 swollen joint counts, the erythrocyte sedimentation rate (ESR), and the patient's assessment of global disease activity (assessed on a visual analog scale \[VAS\] from 0 to 10 cm) are included in the DAS28. If the ESR value is missing, the C-reactive protein (CRP) value can be substituted. Scores on the DAS28 range from 0 to 10; higher scores indicate more disease activity.
Low disease activity is defined as a DAS28 score ≤ 3.2; Moderate disease activity as a DAS28 \>3.2 to ≤5.1; High disease activity as a DAS28 \>5.1.Erythrocyte Sedimentation Rate (ESR) Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 Erythrocyte sedimentation rate (ESR) indirectly measures how much inflammation is in the body. A higher ESR is indicative of increased inflammation.
C-Reactive Protein (CRP) Levels Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 C-Reactive Protein (CRP) was measured from blood samples as a marker for inflammation. Higher levels are indicative of more inflammation. Normal concentration in healthy human serum is usually lower than 10 mg/L, slightly increasing with age.
Tender Joint Count (TJC) Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 Twenty-eight joints were assessed and classified as tender/not tender by pressure and joint manipulation on physical examination.
Swollen Joint Count (SJC) Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 Twenty-eight joints were assessed and classified as swollen/not swollen by pressure and joint manipulation on physical examination.
Hannover Functional Questionnaire (FFbH) Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 A self-administered patient questionnaire used to assess patient function based on 18 questions. The numerically coded responses to the questions are added to provide a total patient score. The FFbH was calculated from this patient score by the following formula:
FFbH = (patient score x 100) ÷ 2 (number of valid responses). The resulting FFbH score reflects the degree of remaining functional capacity where 0 indicates maximal impairment and 100 indicates maximal functional capacity.Patients Global Assessment of Disease Activity Over Time Baseline and Months 3, 6, 9, 12, 18 and 24 Participants indicated their global assessment of disease activity over the last 7 days on a visual analog scale (VAS) from 0 (best) to 10 (worst) cm; lower scores indicate better patient status.
Participants Assessment of Fatigue Over Time Baseline and Month 3, 6, 9, 12, 18, and 24 Participants indicated their level of fatigue over the last 7 days on a visual analog scale (VAS) from 0 (best) to 10 (worst) cm; lower scores indicate better patient status.
Participants Assessment of Pain Over Time Baseline and Months 3, 6, 9, 12, 18, and 24 Participants indicated their level of pain over the last 7 days on a visual analog scale (VAS) from 0 (best) to 10 (worst) cm; lower scores indicate better patient status.
Percentage of Participants With Impairment in Daily Activities Baseline and Months 3, 6, 9, 18, and 24 Participants were asked to report how many days of impairment in daily activities they had experienced in the last 4 weeks.
Number of Days Missed From Work Due to Rheumatoid Arthritis Baseline and Months 6, 12, 18, and 24 Participants reported the number of days they had missed from work in the prior 6 months. The Baseline measurement includes data for the prior 12 months.
Percentage of Participants With In-patient Hospitalization Month 6, 12, 18, and 24 The percentage of participants with in-patient hospitalization in the prior 6 months. Baseline data includes in-patient hospitalizations that occurred within the prior 12 months.
Percentage of Participants on Concomitant Rheumatoid Arthritis and Pain Relief/Anti-inflammatory Medication Baseline and Months 3, 6, 9, 12, 18, and 24
Trial Locations
- Locations (303)
Site Reference ID/Investigator# 35578
🇩🇪Bad Neuenahr, Germany
Site Reference ID/Investigator# 102216
🇩🇪Bad Nauheim, Germany
Site Reference ID/Investigator# 33404
🇩🇪Bad Rappenau, Germany
Site Reference ID/Investigator# 33396
🇩🇪Bad Muender, Germany
Site Reference ID/Investigator# 51883
🇩🇪Bad Salzungen, Germany
Site Reference ID/Investigator# 34998
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34974
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 33808
🇩🇪Heidelberg, Germany
Site Reference ID/Investigator# 33674
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33412
🇩🇪Bad Soden-Salmuenster, Germany
Site Reference ID/Investigator# 33641
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 35089
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33446
🇩🇪Bayreuth, Germany
Site Reference ID/Investigator# 35597
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33792
🇩🇪Harrislee, Germany
Site Reference ID/Investigator# 35019
🇩🇪Hanau, Germany
Site Reference ID/Investigator# 34994
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 33425
🇩🇪Baden-Baden, Germany
Site Reference ID/Investigator# 33648
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33855
🇩🇪Illertissen, Germany
Site Reference ID/Investigator# 35527
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33950
🇩🇪Kaiserslautern, Germany
Site Reference ID/Investigator# 35119
🇩🇪Heidelberg, Germany
Site Reference ID/Investigator# 33620
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 35464
🇩🇪Heidenheim, Germany
Site Reference ID/Investigator# 35125
🇩🇪Kahla, Germany
Site Reference ID/Investigator# 33661
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 34266
🇩🇪Berlin-Buch, Germany
Site Reference ID/Investigator# 33946
🇩🇪Kahla, Germany
Site Reference ID/Investigator# 34002
🇩🇪Koenigs Wusterhausen, Germany
Site Reference ID/Investigator# 35262
🇩🇪Ludwigshafen, Germany
Site Reference ID/Investigator# 35292
🇩🇪Muelheim, Germany
Site Reference ID/Investigator# 35276
🇩🇪Mainz, Germany
Site Reference ID/Investigator# 34043
🇩🇪Munich, Germany
Site Reference ID/Investigator# 34052
🇩🇪Naunhof, Germany
Site Reference ID/Investigator# 34064
🇩🇪Neuburg, Germany
Site Reference ID/Investigator# 34061
🇩🇪Neubrandenburg, Germany
Site Reference ID/Investigator# 34076
🇩🇪Neustadt, Germany
Site Reference ID/Investigator# 51882
🇩🇪Jena, Germany
Site Reference ID/Investigator# 34005
🇩🇪Lahr, Germany
Site Reference ID/Investigator# 35057
🇩🇪Arnstadt, Germany
Site Reference ID/Investigator# 34106
🇩🇪Leipzig, Germany
Site Reference ID/Investigator# 35245
🇩🇪Landau, Germany
Site Reference ID/Investigator# 35550
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 35551
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 35295
🇩🇪Munich, Germany
Site Reference ID/Investigator# 34229
🇩🇪Muellheim, Germany
Site Reference ID/Investigator# 34071
🇩🇪Neumuenster, Germany
Site Reference ID/Investigator# 34200
🇩🇪Meissen, Germany
Site Reference ID/Investigator# 34291
🇩🇪Bocholt, Germany
Site Reference ID/Investigator# 34238
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33508
🇩🇪Parchim, Germany
Site Reference ID/Investigator# 34208
🇩🇪Mittelherwigsdorf, Germany
Site Reference ID/Investigator# 34192
🇩🇪Marktredwitz, Germany
Site Reference ID/Investigator# 34196
🇩🇪Marl, Germany
Site Reference ID/Investigator# 34955
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35641
🇩🇪Bochum, Germany
Site Reference ID/Investigator# 35603
🇩🇪Breitenbrunn, Germany
Site Reference ID/Investigator# 35196
🇩🇪Essen, Germany
Site Reference ID/Investigator# 34970
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34742
🇩🇪Dortmund, Germany
Site Reference ID/Investigator# 34932
🇩🇪Halle, Germany
Site Reference ID/Investigator# 35036
🇩🇪Aachen, Germany
Site Reference ID/Investigator# 35043
🇩🇪Altenburg, Germany
Site Reference ID/Investigator# 35046
🇩🇪Altenholz, Germany
Site Reference ID/Investigator# 35224
🇩🇪Friedrichroda, Germany
Site Reference ID/Investigator# 34922
🇩🇪Halle, Germany
Site Reference ID/Investigator# 34887
🇩🇪Giessen, Germany
Site Reference ID/Investigator# 35444
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35007
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35570
🇩🇪Bad Brambach, Germany
Site Reference ID/Investigator# 35219
🇩🇪Freiberg, Germany
Site Reference ID/Investigator# 34896
🇩🇪Goslar, Germany
Site Reference ID/Investigator# 33349
🇩🇪Augsburg, Germany
Site Reference ID/Investigator# 35287
🇩🇪Minden, Germany
Site Reference ID/Investigator# 34224
🇩🇪Muehlhausen, Germany
Site Reference ID/Investigator# 34048
🇩🇪Muenster, Germany
Site Reference ID/Investigator# 34232
🇩🇪Munich, Germany
Site Reference ID/Investigator# 34176
🇩🇪Offenburg, Germany
Site Reference ID/Investigator# 35101
🇩🇪Freystadt, Germany
Site Reference ID/Investigator# 35452
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 33845
🇩🇪Hohenfelde, Germany
Site Reference ID/Investigator# 34883
🇩🇪Gera, Germany
Site Reference ID/Investigator# 34940
🇩🇪Halle, Germany
Site Reference ID/Investigator# 102217
🇩🇪Gross Ammensleben, Germany
Site Reference ID/Investigator# 35449
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34725
🇩🇪Deggendorf, Germany
Site Reference ID/Investigator# 34307
🇩🇪Braunschweig, Germany
Site Reference ID/Investigator# 34901
🇩🇪Greifswald, Germany
Site Reference ID/Investigator# 34773
🇩🇪Duesseldorf, Germany
Site Reference ID/Investigator# 35000
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35615
🇩🇪Coesfeld, Germany
Site Reference ID/Investigator# 35491
🇩🇪Gosheim, Germany
Site Reference ID/Investigator# 35496
🇩🇪Greifswald, Germany
Site Reference ID/Investigator# 35621
🇩🇪Darmstadt, Germany
Site Reference ID/Investigator# 34937
🇩🇪Halle, Germany
Site Reference ID/Investigator# 34952
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34958
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35111
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34904
🇩🇪Greifswald, Germany
Site Reference ID/Investigator# 35611
🇩🇪Celle, Germany
Site Reference ID/Investigator# 34879
🇩🇪Gelsenkirchen, Germany
Site Reference ID/Investigator# 34854
🇩🇪Freiburg, Germany
Site Reference ID/Investigator# 35503
🇩🇪Hagen, Germany
Site Reference ID/Investigator# 34944
🇩🇪Halle, Germany
Site Reference ID/Investigator# 35335
🇩🇪Paderborn, Germany
Site Reference ID/Investigator# 33867
🇩🇪Zeven, Germany
Site Reference ID/Investigator# 33737
🇩🇪Villingen-Schwenningen, Germany
Site Reference ID/Investigator# 35355
🇩🇪Rickenbach, Germany
Site Reference ID/Investigator# 33911
🇩🇪Riesa, Germany
Site Reference ID/Investigator# 33927
🇩🇪Rostock, Germany
Site Reference ID/Investigator# 33902
🇩🇪Rendsburg, Germany
Site Reference ID/Investigator# 33914
🇩🇪Rinteln, Germany
Site Reference ID/Investigator# 34023
🇩🇪Salzwedel, Germany
Site Reference ID/Investigator# 33751
🇩🇪Weissenfels, Germany
Site Reference ID/Investigator# 33923
🇩🇪Rostock, Germany
Site Reference ID/Investigator# 35397
🇩🇪Voehringen, Germany
Site Reference ID/Investigator# 35510
🇩🇪Ahlen, Germany
Site Reference ID/Investigator# 33358
🇩🇪Bad Abbach, Germany
Site Reference ID/Investigator# 35040
🇩🇪Ahrensburg, Germany
Site Reference ID/Investigator# 35049
🇩🇪Amberg, Germany
Site Reference ID/Investigator# 33361
🇩🇪Bad Abbach, Germany
Site Reference ID/Investigator# 33372
🇩🇪Bad Endbach, Germany
Site Reference ID/Investigator# 35142
🇩🇪Bad Aibling, Germany
Site Reference ID/Investigator# 35573
🇩🇪Bad Bramstedt, Germany
Site Reference ID/Investigator# 33378
🇩🇪Bad Iburg, Germany
Site Reference ID/Investigator# 33382
🇩🇪Bad Iburg, Germany
Site Reference ID/Investigator# 33387
🇩🇪Bad Kreuznach, Germany
Site Reference ID/Investigator# 35575
🇩🇪Bad Kreuznach, Germany
Site Reference ID/Investigator# 33391
🇩🇪Bad Liebenwerda, Germany
Site Reference ID/Investigator# 33442
🇩🇪Bayreuth, Germany
Site Reference ID/Investigator# 33693
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 34252
🇩🇪Berlin-Wannsee, Germany
Site Reference ID/Investigator# 34269
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33670
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 34246
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33704
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 35556
🇩🇪Bernau, Germany
Site Reference ID/Investigator# 33690
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33687
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 34277
🇩🇪Biberach, Germany
Site Reference ID/Investigator# 35562
🇩🇪Binzen, Germany
Site Reference ID/Investigator# 34302
🇩🇪Bonn, Germany
Site Reference ID/Investigator# 34288
🇩🇪Blaubeuren, Germany
Site Reference ID/Investigator# 35566
🇩🇪Bocholt, Germany
Site Reference ID/Investigator# 34699
🇩🇪Chemnitz, Germany
Site Reference ID/Investigator# 33989
🇩🇪Cologne, Germany
Site Reference ID/Investigator# 35237
🇩🇪Cologne, Germany
Site Reference ID/Investigator# 34708
🇩🇪Cottbus, Germany
Site Reference ID/Investigator# 35631
🇩🇪Dessau-Rosslau, Germany
Site Reference ID/Investigator# 35635
🇩🇪Dortmund, Germany
Site Reference ID/Investigator# 35634
🇩🇪Dortmund, Germany
Site Reference ID/Investigator# 35170
🇩🇪Dresden, Germany
Site Reference ID/Investigator# 34784
🇩🇪Eberswalde, Germany
Site Reference ID/Investigator# 34754
🇩🇪Dresden, Germany
Site Reference ID/Investigator# 34748
🇩🇪Dresden, Germany
Site Reference ID/Investigator# 34778
🇩🇪Duisburg, Germany
Site Reference ID/Investigator# 35184
🇩🇪Elmshorn, Germany
Site Reference ID/Investigator# 34809
🇩🇪Erfurt, Germany
Site Reference ID/Investigator# 35191
🇩🇪Erfurt, Germany
Site Reference ID/Investigator# 34821
🇩🇪Erlangen, Germany
Site Reference ID/Investigator# 35202
🇩🇪Feldafing, Germany
Site Reference ID/Investigator# 34849
🇩🇪Frankfurt, Germany
Site Reference ID/Investigator# 34840
🇩🇪Frankfurt, Germany
Site Reference ID/Investigator# 35205
🇩🇪Flensburg, Germany
Site Reference ID/Investigator# 34833
🇩🇪Forchheim, Germany
Site Reference ID/Investigator# 35213
🇩🇪Fraureuth, Germany
Site Reference ID/Investigator# 34843
🇩🇪Frankfurt, Germany
Site Reference ID/Investigator# 34961
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 34986
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 33712
🇩🇪Hanover, Germany
Site Reference ID/Investigator# 35459
🇩🇪Haseluenne, Germany
Site Reference ID/Investigator# 102215
🇩🇪Heidelberg, Germany
Site Reference ID/Investigator# 33825
🇩🇪Herrsching, Germany
Site Reference ID/Investigator# 33842
🇩🇪Hofheim, Germany
Site Reference ID/Investigator# 33834
🇩🇪Hof, Germany
Site Reference ID/Investigator# 33858
🇩🇪Immenstadt, Germany
Site Reference ID/Investigator# 33942
🇩🇪Juelich, Germany
Site Reference ID/Investigator# 33964
🇩🇪Kassel, Germany
Site Reference ID/Investigator# 34008
🇩🇪Kressbronn, Germany
Site Reference ID/Investigator# 34084
🇩🇪Kronach, Germany
Site Reference ID/Investigator# 34112
🇩🇪Leipzig, Germany
Site Reference ID/Investigator# 34109
🇩🇪Leipzig, Germany
Site Reference ID/Investigator# 34100
🇩🇪Leipzig, Germany
Site Reference ID/Investigator# 35254
🇩🇪Lippstadt, Germany
Site Reference ID/Investigator# 35306
🇩🇪Ludwigsfelde, Germany
Site Reference ID/Investigator# 34139
🇩🇪Lueneburg, Germany
Site Reference ID/Investigator# 34147
🇩🇪Magdeburg, Germany
Site Reference ID/Investigator# 35285
🇩🇪Menz, Germany
Site Reference ID/Investigator# 34218
🇩🇪Moenchengladbach, Germany
Site Reference ID/Investigator# 34221
🇩🇪Moenkeberg, Germany
Site Reference ID/Investigator# 34040
🇩🇪Munich, Germany
Site Reference ID/Investigator# 35298
🇩🇪Munich, Germany
Site Reference ID/Investigator# 35321
🇩🇪Niederbrombach, Germany
Site Reference ID/Investigator# 34016
🇩🇪Saarbruecken, Germany
Site Reference ID/Investigator# 33734
🇩🇪Viersen, Germany
Site Reference ID/Investigator# 33742
🇩🇪Waltrop, Germany
Site Reference ID/Investigator# 34027
🇩🇪Sande, Germany
Site Reference ID/Investigator# 33931
🇩🇪Rothenburg, Germany
Site Reference ID/Investigator# 35404
🇩🇪Wiefelstede, Germany
Site Reference ID/Investigator# 33761
🇩🇪Wiesbaden, Germany
Site Reference ID/Investigator# 35408
🇩🇪Wiesbaden, Germany
Site Reference ID/Investigator# 33765
🇩🇪Wiesbaden, Germany
Site Reference ID/Investigator# 35413
🇩🇪Wiesbaden, Germany
Site Reference ID/Investigator# 33772
🇩🇪Wilhelmshaven, Germany
Site Reference ID/Investigator# 33780
🇩🇪Wittlich, Germany
Site Reference ID/Investigator# 33718
🇩🇪Wuerzburg, Germany
Site Reference ID/Investigator# 33873
🇩🇪Zwickau, Germany
Site Reference ID/Investigator# 33880
🇩🇪Zwiesel, Germany
Site Reference ID/Investigator# 35420
🇩🇪Wuppertal, Germany
Site Reference ID/Investigator# 33864
🇩🇪Zerbst, Germany
Site Reference ID/Investigator# 35210
🇩🇪Frankenberg, Germany
Site Reference ID/Investigator# 33749
🇩🇪Weener, Germany
Site Reference ID/Investigator# 33852
🇩🇪Welzow, Germany
Site Reference ID/Investigator# 35096
🇩🇪Erfurt, Germany
Site Reference ID/Investigator# 35520
🇩🇪Attendorn, Germany
Site Reference ID/Investigator# 33429
🇩🇪Bamberg, Germany
Site Reference ID/Investigator# 33438
🇩🇪Bautzen, Germany
Site Reference ID/Investigator# 33697
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33658
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 33683
🇩🇪Berlin, Germany
Site Reference ID/Investigator# 34296
🇩🇪Bonn, Germany
Site Reference ID/Investigator# 34285
🇩🇪Blankenburg/Hart, Germany
Site Reference ID/Investigator# 35644
🇩🇪Bogen, Germany
Site Reference ID/Investigator# 35646
🇩🇪Bonn, Germany
Site Reference ID/Investigator# 35652
🇩🇪Bottrop, Germany
Site Reference ID/Investigator# 35093
🇩🇪Chemnitz, Germany
Site Reference ID/Investigator# 35609
🇩🇪Bremen, Germany
Site Reference ID/Investigator# 34711
🇩🇪Cottbus, Germany
Site Reference ID/Investigator# 35199
🇩🇪Essen, Germany
Site Reference ID/Investigator# 34751
🇩🇪Dresden, Germany
Site Reference ID/Investigator# 34760
🇩🇪Dresden, Germany
Site Reference ID/Investigator# 34768
🇩🇪Duesseldorf, Germany
Site Reference ID/Investigator# 34861
🇩🇪Freiburg, Germany
Site Reference ID/Investigator# 35221
🇩🇪Freiburg, Germany
Site Reference ID/Investigator# 34912
🇩🇪Guestrow, Germany
Site Reference ID/Investigator# 35441
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35498
🇩🇪Guben, Germany
Site Reference ID/Investigator# 34983
🇩🇪Hamburg, Germany
Site Reference ID/Investigator# 35025
🇩🇪Hanover, Germany
Site Reference ID/Investigator# 33798
🇩🇪Heidelberg, Germany
Site Reference ID/Investigator# 33801
🇩🇪Heidelberg, Germany
Site Reference ID/Investigator# 33818
🇩🇪Heilbad Heiligenstadt, Germany
Site Reference ID/Investigator# 35479
🇩🇪Ingolstadt, Germany
Site Reference ID/Investigator# 33961
🇩🇪Karlsruhe, Germany
Site Reference ID/Investigator# 33956
🇩🇪Karlsruhe, Germany
Site Reference ID/Investigator# 34136
🇩🇪Luebeck, Germany
Site Reference ID/Investigator# 34150
🇩🇪Magdeburg, Germany
Site Reference ID/Investigator# 34213
🇩🇪Moenchengladbach, Germany
Site Reference ID/Investigator# 34235
🇩🇪Munich, Germany
Site Reference ID/Investigator# 34080
🇩🇪Niefern-Oeschelbronn, Germany
Site Reference ID/Investigator# 34173
🇩🇪Oelsnitz, Germany
Site Reference ID/Investigator# 34158
🇩🇪Nienburg, Germany
Site Reference ID/Investigator# 33492
🇩🇪Oldenburg, Germany
Site Reference ID/Investigator# 34718
🇩🇪Ostseebad Damp, Germany
Site Reference ID/Investigator# 33517
🇩🇪Pfullendorf, Germany
Site Reference ID/Investigator# 35340
🇩🇪Passau, Germany
Site Reference ID/Investigator# 33528
🇩🇪Plauen, Germany
Site Reference ID/Investigator# 67482
🇩🇪Pirna, Germany
Site Reference ID/Investigator# 33470
🇩🇪Potsdam, Germany
Site Reference ID/Investigator# 33523
🇩🇪Planegg, Germany
Site Reference ID/Investigator# 33466
🇩🇪Potsdam, Germany
Site Reference ID/Investigator# 33476
🇩🇪Pruem, Germany
Site Reference ID/Investigator# 33479
🇩🇪Puettlingen, Germany
Site Reference ID/Investigator# 35136
🇩🇪Ratingen, Germany
Site Reference ID/Investigator# 35347
🇩🇪Radebeul, Germany
Site Reference ID/Investigator# 33484
🇩🇪Radebeul, Germany
Site Reference ID/Investigator# 33890
🇩🇪Regensburg, Germany
Site Reference ID/Investigator# 33488
🇩🇪Ratzeburg, Germany
Site Reference ID/Investigator# 33883
🇩🇪Regensburg, Germany
Site Reference ID/Investigator# 33897
🇩🇪Reken, Germany
Site Reference ID/Investigator# 33886
🇩🇪Regensburg, Germany
Site Reference ID/Investigator# 33907
🇩🇪Rheine, Germany
Site Reference ID/Investigator# 35362
🇩🇪Ruedersdorf, Germany
Site Reference ID/Investigator# 33534
🇩🇪Schneeberg, Germany
Site Reference ID/Investigator# 33539
🇩🇪Schramberg, Germany
Site Reference ID/Investigator# 35371
🇩🇪Schwandorf, Germany
Site Reference ID/Investigator# 33549
🇩🇪Schwerin, Germany
Site Reference ID/Investigator# 33555
🇩🇪Schwerte, Germany
Site Reference ID/Investigator# 33542
🇩🇪Schutterwald, Germany
Site Reference ID/Investigator# 35376
🇩🇪Schwerin, Germany
Site Reference ID/Investigator# 33563
🇩🇪Senden, Germany
Site Reference ID/Investigator# 33559
🇩🇪Seesen, Germany
Site Reference ID/Investigator# 35380
🇩🇪Singen, Germany
Site Reference ID/Investigator# 33567
🇩🇪Sinsheim, Germany
Site Reference ID/Investigator# 33577
🇩🇪Spremberg, Germany
Site Reference ID/Investigator# 33572
🇩🇪Soltau, Germany
Site Reference ID/Investigator# 35383
🇩🇪St. Martin, Germany
Site Reference ID/Investigator# 33588
🇩🇪Stadthagen, Germany
Site Reference ID/Investigator# 33592
🇩🇪Steinhagen, Germany
Site Reference ID/Investigator# 33604
🇩🇪Stuttgart, Germany
Site Reference ID/Investigator# 33607
🇩🇪Stuttgart, Germany
Site Reference ID/Investigator# 33598
🇩🇪Stuttgart, Germany
Site Reference ID/Investigator# 33611
🇩🇪Stuttgart, Germany
Site Reference ID/Investigator# 35389
🇩🇪Suhl, Germany
Site Reference ID/Investigator# 35391
🇩🇪Tegernau, Germany
Site Reference ID/Investigator# 33625
🇩🇪Torgelow, Germany
Site Reference ID/Investigator# 33721
🇩🇪Ulm, Germany
Site Reference ID/Investigator# 33724
🇩🇪Ulm, Germany
Site Reference ID/Investigator# 33637
🇩🇪Ueberlingen-Nussdorf, Germany
Site Reference ID/Investigator# 35395
🇩🇪Uffenheim, Germany
Site Reference ID/Investigator# 33876
🇩🇪Zwickau, Germany
Site Reference ID/Investigator# 35313
🇩🇪Neuss, Germany