Predicting Outcomes of Breast-Conserving Surgery in Breast Cancer Patients Using the Modified 5-Item Frailty Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 96,586
- 试验地点
- 1
- 主要终点
- General data
研究概览
简要总结
Background: Breast cancer is the most common malignancy among women worldwide, with breast-conserving surgery (BCS) being a key treatment. The modified 5-item frailty index (mFI-5), a well-validated tool for assessing frailty, has shown predictive utility in other surgical contexts but remains under-explored in BCS.
Methods: Using the American College of Surgeons National Surgical Quality Improvement Program database (2008-2021), the investigators identified adult female breast cancer patients who underwent BCS. Frailty was assessed using the mFI-5, scored from 0 to 5, with higher scores indicating greater frailty. Multivariable logistic regression was employed to evaluate associations between mFI-5 scores and postoperative outcomes.
Main question: Can the mFI-5 predict adverse postoperative outcomes in breast-conserving surgery patients?
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
General data
时间窗: 30 days
* Hospital length of stay (in days). * Operative time (in minutes).
Any complications
时间窗: 30 days
* Patient mortality. * (Unplanned) readmission. * Surgical and/or medical complications.
Surgical Complications
时间窗: 30 days
* Infections (superficial, deep, or organ-space). * Wound dehiscence. * Bleeding requiring transfusion.
Medical Complications
时间窗: 30 days
* Pneumonia. * Reintubation. * Pulmonary embolism. * Ventilator dependence \>48 hours. * Progressive renal insufficiency. * Urinary tract infection. * Stroke or cerebrovascular accident. * Myocardial infarction. * Deep vein thrombosis or thrombophlebitis. * Sepsis. * Septic shock.
次要结局
未报告次要终点