Ong-term Oncologic Outcome of Breast-conserving Surgery in Breast Cancer Patients With BRCA1/2 Mutations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 4,010
- 试验地点
- 1
- 主要终点
- Recurrence-free survival
研究概览
简要总结
The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients in breast cancer patients with BRCA 1/2 mutations.
详细描述
The purpose of study is to assess the oncologic safety of BCS in patients carrying BRCA1/2 mutations by comparing long-term outcomes with mastectomy. The investigators matched BCS and mastectomy group using propensity scores and analyzed the recurrence and survival among the evenly matched patients. By providing insights into the feasibility of BCS for patients with BRCA1/2 mutations, the investigators aim to present evidence to aid in surgical decision-making for the care of these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Primary invasive breast cancer who underwent BCS or mastectomy
- •Received a BRCA1/2 mutation test
排除标准
- •Patients with de novo metastasis
- •Pregnancy-associated breast cancer
结局指标
主要结局
Recurrence-free survival
时间窗: Duration from diagnosis until the development of recurrence up to 10year
Any form of disease recurrence
Distant recurrence-free survival
时间窗: Duration from diagnosis until the development of recurrence up to 10year
Recurrence in a distant organ
Locoregional recurrence-free survival
时间窗: Duration from diagnosis until the development of recurrence up to 10year
Recurrence in breast or chest wall and/or regional lymph nodes
次要结局
未报告次要终点