Feasibility of the use of Ultrasound Doppler-derived patient-specific velocity profiles in fluid-structure interaction modelling of the abdominal aorta, femoral artery and carotid artery

Recruiting

Conditions: 'Aneurysm'
'Dilated artery'
'Narrowed artery'
'Stenosis'
10002363

Registration Number: NL-OMON53799

Lead Sponsor: Catharina-ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 48

Inclusion Criteria

The main inclusion criterium for the patients is that they have an abdominal
aortic aneurysm or a femoral artery or carotid artery stenosis. Furthermore,
the patients should be under surveillance at the Catharina hospital for their
stenosis or aneurysm. For the AAA patients, an additional inclusion criterium
is that they are involved in the longitudinal study (research mentioned in B2).
The volunteers should be in the age of 18-65 and not diagnosed with a
cardiovascular disease.

Exclusion Criteria

Minors, incapacitated adults and mentally incompetent adults will not be
included in the study. Subjects that do not want to participate will also not
be included. Furthermore, also patients and volunteers that suffer from
claustrophobia will be excluded from the study. Lastly, the patients and
volunteers will be screened for metallic foreign bodies. In case that metallic
foreign bodies are present the patients and volunteers will not be included in
the study.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Patient specific velocity profile over time and cross section of the abdominal<br /><br>aorta, carotid artery and femoral artery obtained with Ultrasound Doppler and<br /><br>compared with 4D flow MRI (abdominal aorta) or 2D PCMRI (femoral and carotid<br /><br>artery). This patient specific velocity profile will be used in FSI simulations<br /><br>of AAA's, carotid artery stenoses and femoral artery stenoses.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary goal of this study is to validate the FSI model. With 4D flow<br />MRI, the velocity streamlines can be constructed, which can then be compared to<br />the streamlines from the FSI model. In addition, based on the velocity measured<br />with 4D flow MRI, the Wall Shear Stress (WSS) and Oscillatory Shear Index (OSI)<br />can be calculated, which can also be compared to the WSS and OSI as predicted<br />by the FSI model. Also the with MRI measured wall displacements will be<br />compared to the with FSI simulated wall displacements. Lastly, the 4D flow MRI<br />data will also be used for the validation of the stiffness of the aortic wall.</p>