Genetic variation in patients with cerebral palsy

Completed

• Conditions: Cerebral palsy; Nervous System Diseases; Muscle contractures in cerebral palsy patients

• Registration Number: ISRCTN15926751
• Lead Sponsor: niversity of Copenhagen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-07
• Last Update Posted: 3 July 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Cerebral palsy (CP) group:
1. Patients with cerebral palsy in all severity of CP
2. The patient is either over 18 years of age or
3. The patient's parents are legitimate

Healthy participants:
1. Healthy subjects
2. The test person is over 18 years old and authoritative
3. The subjects have no previous musculoskeletal disorders

Exclusion Criteria

Cerebral palsy (CP) group:
Individuals with CP without contractures.

Healthy participants:
1. Previous brain injuries
2. Skeletal muscle diseases

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genetic variants of 96 candidate genes are measured using next generation sequencing and then aligned to a human reference gene (hg19) following the study visit.

Secondary Outcome Measures

Name	Time	Method
Gross motor function is assessed through collection of Gross Motor Function Classification System (GMFCS) scores at the study visit.